The goal of this study was to examine humoral mechanisms that regulate blood flow to the choroid plexus. We determined the effects of arginine vasopressin on blood flow (microspheres) to the choroid plexus in anesthetized and awake rabbits. In anesthetized rabbits, blood flow to the choroid plexus was 342 +/- 31 (mean +/- SEM) ml/min/100 g under control conditions. Intravenous infusion of vasop...

1. Lignocaine readily passes from blood into cerebrospinal fluid. The isolated rabbit choroid plexus, a locus of the blood-cerebrospinal fluid barrier, accumulated [14C]lignocaine by two processess: an active, saturable transport process and a non-saturable process. 2. The accumulation of [14C]lignocaine by choroid plexus was not due to non-specific binding or metabolism of lignocaine within or...

VERHEGGEN, I.C.M., W. Freeze, J. de Jong, Jansen, A. Postma, M. van Boxtel, F. Verhey and Backes. The application of contrast-enhanced MRI in the assessment blood-cerebrospinal fluid barrier integrity. Choroid plexus epithelial cells form a that enables active, bidirectional exchange between blood plasma cerebrospinal (CSF), known as blood-CSF (BCSFB). Through its involvement CSF composition, B...

A case report is presented of an axillary plexus blockade following a second toe-to-hand transfer. After completion of the microvascular anastomoses and restoration of blood flow to the transplanted toe, the axillary plexus blockade was started. Together with the vasodilation of the hand and forearm there was a marked drop in blood flow in the transplanted toe. Possible explanations for this ph...

Thyroid hormones are key players in regulating brain development. Thus, transfer of appropriate quantities of thyroid hormones from the blood into the brain at specific stages of development is critical. The choroid plexus forms the blood-cerebrospinal fluid barrier. In reptiles, birds and mammals, the main protein synthesized and secreted by the choroid plexus is a thyroid hormone distributor ...

Although heavy metal ions are known to be toxic to the central nervous system (CNS), the mechanisms by which the CNS may protect itself from initial challenges of such toxic ions is unknown. The choroid plexus is the principal site of formation of the cerebrospinal fluid (CSF) which bathes the brain. We have determined in rats and rabbits that after intraperitoneal administration of lead, cadmi...

Lead (Pb) exposure reportedly modulates PKC activity in brain endothelial preparations, which may underlie Pb-induced damage at the blood-brain barrier. Our previous work indicates that Pb accumulates in the choroid plexus and causes dysfunction of this blood-cerebrospinal fluid (CSF) barrier. The present studies were undertaken to test the hypothesis that Pb in the choroid plexus may alter PKC...