INTRODUCTION The Comprehensive Chronic Care Programme (CCCP) is an intensified programme designed to provide comprehensive care for the management of diabetes mellitus, hypertension and hyperlipidaemia at a primary healthcare setting. A formative study was done to evaluate the effectiveness of the CCCP compared to the normal polyclinic management of diabetes mellitus. MATERIALS AND METHODS Co...

The effects of mitochondrial uncoupling on the calcium homeostasis of prostatic cells were investigated using the prostatic cancer cell line LNCaP and indo-1 spectrofluorimetry. Carbonyl cyanide m-chloro-phenylhydrazone (CCCP) was used as uncoupler. Resting LNCaP cells responded to CCCP by a biphasic increase in [Ca2+]i. The first phase of increase which corresponded to the release of a mitocho...

Cytochrome c oxidase binds protonophore carbonyl cyanide 3-chlorophenylhydrazone (CCCP) with high affinity. There are 1.46 high-affinity binding sites per cytochrome c oxidase for CCCP with dissociation constant 2.7 x 10(-7) mol/l. The bond between the CCCP and cytochrome c oxidase accomplishes through the group on cytochrome c oxidase with pKa 6.64 and is based on the electrostatic interaction...

The concave-convex procedure (CCCP) is an iterative algorithm that solves d.c. (difference of convex functions) programs as a sequence of convex programs. In machine learning, CCCP is extensively used in many learning algorithms, including sparse support vector machines (SVMs), transductive SVMs, and sparse principal component analysis. Though CCCP is widely used in many applications, its conve...

The concave-convex procedure (CCCP) is a majorization-minimization algorithm that solves d.c. (difference of convex functions) programs as a sequence of convex programs. In machine learning, CCCP is extensively used in many learning algorithms like sparse support vector machines (SVMs), transductive SVMs, sparse principal component analysis, etc. Though widely used in many applications, the con...

Dense-core vesicles (DCVs) are secretory organelles that store and release modulatory neurotransmitters from neurons and endocrine cells. Recently, the conserved coiled-coil protein CCCP-1 was identified as a component of the DCV biogenesis pathway in the nematode Caenorhabditis elegans. CCCP-1 binds the small GTPase RAB-2 and colocalizes with it at the trans-Golgi. Here, we report a structure-...

The k-sat problem is a prototypical constraint satisfaction problem. There are many algorithms to study k-sat problem, BP algorithm is famous one of them. But BP algorithm does not converge when α(constraint density)is bigger than some threshold value. In this paper we use CCCP (Concave Convex Procedure) algorithm to study 3-sat problem and we get better results than BP algorithm that CCCP algo...

We introduce the Concave-Convex procedure (CCCP) which constructs discrete time iterative dynamical systems which are guaranteed to monotonically decrease global optimization/energy functions. It can be applied to (almost) any optimization problem and many existing algorithms can be interpreted in terms of CCCP. In particular, we prove relationships to some applications of Legendre transform te...

Concave-Convex Procedure (CCCP) has been widely used to solve nonconvex d.c.(difference of convex function) programs occur in learning problems, such as sparse support vector machine (SVM), transductive SVM, sparse principal componenent analysis (PCA), etc. Although the global convergence behavior of CCCP has been well studied, the convergence rate of CCCP is still an open problem. Most of d.c....

Photoreceptor degeneration is mediated by apoptosis in several animal models, although the underlying mechanisms are yet to be elucidated. We present here an apoptotic model based on a primary cell culture of tiger salamander photoreceptors, in which treatment with carbonyl cyanide m-chlorophenylhydrazone (cccp), a protonophore, induced apoptosis. Cells exposed to cccp showed condensed nuclei a...