نتایج جستجو برای CD11c

تعداد نتایج: 1917  

2013
Liisa M. Uotila, Maria Aatonen, Carl G. Gahmberg,

Background: Leukocyte integrins are involved in cell adhesion, cell migration, and phagocytosis. Results: CD11c/CD18, a leukocyte integrin expressed on monocytes, macrophages, and dendritic cells, is phosphorylated on Ser-1158 of the -chain. Abrogation of phosphorylation results in impaired adhesion and phagocytosis. Conclusion: Integrin inside-out activated adhesion is regulated by a single ph...

Journal: :Journal of immunology 1999
N Kohrgruber, N Halanek, M Gröger, D Winter, K Rappersberger, M Schmitt-Egenolf, G Stingl, D Maurer,

Two types of dendritic cells (DC) are circulating in human blood and can be identified by their differential expression of the myeloid Ag CD11c. In this study, we show that CD11c- peripheral blood (PB)-DC correspond to plasmacytoid DC of lymphoid tissue not only by their surface Ag expression profile but, more impressively, by their peculiar ultramorphology. We also demonstrate that CD11c- and ...

Journal: :The Journal of Experimental Medicine 1995
R R Ingalls, D T Golenbock,

CD11c/CD18 is a member of the leukocyte integrin family, heterodimeric adhesion molecules that interact with a diverse repertoire of ligands, including bacterial lipopolysaccharide (LPS). Their role as signal transducing receptors remains uncertain. We used a heterologous expression system to determine if CD11c/CD18 was capable of initiating signal transduction in response to LPS-binding, as as...

Journal: :The European respiratory journal 2009
M Girard, E Israël-Assayag, Y Cormier,

The present study verified the hypothesis that enhanced maturation of antigen-presenting CD11c(+) cells could explain the viral-induced exacerbated immune response to Saccharopolyspora rectivirgula (SR), the main antigen responsible for farmer's lung, a classic form of hypersensitivity pneumonitis (HP). Four groups of mice were studied: group 1 received intranasal instillations of saline; group...

Journal: :Blood 1992
H M Prince, J Bashford, M B van der Weyden,

2007
Thomas Vorup-Jensen, Lianli Chi, Louise C. Gjelstrup, Uffe B. Jensen, Craig A. Jewett, Can Xie, Motomu Shimaoka, Robert J. Linhardt, Timothy A. Springer,

Thomas Vorup-Jensen, Lianli Chi, Louise C. Gjelstrup, Uffe B. Jensen, Craig A. Jewett, Can Xie, Motomu Shimaoka**, Robert J. Linhardt, and Timothy A. Springer From the Immune Disease Institute (formerly CBR Institute for Biomedical Research), Departments of Pathology and **Anesthesia, Harvard Medical School, Boston, Massachusetts 02115, the Biophysical Immunology Laboratory, Institute of Medica...

Journal: :The EMBO journal 2016
Magdalena Paterka, Volker Siffrin, Jan O Voss, Johannes Werr, Nicola Hoppmann, René Gollan, Patrick Belikan, Julia Bruttger, Jérôme Birkenstock, Steffen Jung, Enric Esplugues, Nir Yogev, Richard A Flavell, Tobias Bopp, Frauke Zipp,

Multiple sclerosis is the most frequent chronic inflammatory disease of the CNS. The entry and survival of pathogenic T cells in the CNS are crucial for the initiation and persistence of autoimmune neuroinflammation. In this respect, contradictory evidence exists on the role of the most potent type of antigen-presenting cells, dendritic cells. Applying intravital two-photon microscopy, we demon...

Journal: :European review for medical and pharmacological sciences 2014
W-Z Pan, C-X Shi, M Tian, J-G Yu,

BACKGROUND The pathophysiology of ventilator-induced lung injury (VILI) involves multiple mechanisms including inflammation and inflammatory cells infiltration. The anti-CD11c monoclonal antibody, Efalizumab has been demonstrated to inhibit the T cell activation, migration and adhesion to keratinocytes. MATERIALS AND METHODS In this study, we induced lung injury with mechanical ventilation in...

2017
Dan Wang, Gwen M. Taylor, James R. Gilbert, Joseph E. Losee, Chhinder P. Sodhi, David J. Hackam, Timothy R. Billiar, Gregory M. Cooper,

BACKGROUND Inflammation is integral to the injury response. The inflammatory response is essential to the host defense against infection and also to tissue regeneration and repair. Toll-like receptors (TLRs) are critical activators of the innate immune response and present attractive therapeutic targets for inflammation-modulated tissue regeneration. The authors' previous study showed that depl...

2010
Alexander T. Phythian-Adams, Peter C. Cook, Rachel J. Lundie, Lucy H. Jones, Katherine A. Smith, Tom A. Barr, Kristin Hochweller, Stephen M. Anderton, Günter J. Hämmerling, Rick M. Maizels, Andrew S. MacDonald,

Although dendritic cells (DCs) are adept initiators of CD4(+) T cell responses, their fundamental importance in this regard in Th2 settings remains to be demonstrated. We have used CD11c-diphtheria toxin (DTx) receptor mice to deplete CD11c(+) cells during the priming stage of the CD4(+) Th2 response against the parasitic helminth Schistosoma mansoni. DTx treatment significantly depleted CD11c(...

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