نتایج جستجو برای: CD56

تعداد نتایج: 2742  

Mahbubeh Soofi Nader Tajik, Parisa Farnia Tahereh Mousavi,

Background: Protective immune responses induced in the majority of people infected with Mycobacterium tuberculosis enable them to control TB infection. Objective: The aim of this study was to investigate CD56 and CD16 positive peripheral blood mononu-clear cells (PBMCs) and leukocyte subsets from multi-drug resistant pulmonary tuber-culosis (MDR-TB), and compare them with nonresistant (NR) TB p...

Journal: :Blood 2010
Jianhua Yu Hsiaoyin C Mao Min Wei Tiffany Hughes Jianying Zhang Il-kyoo Park Shujun Liu Susan McClory Guido Marcucci Rossana Trotta Michael A Caligiuri

Human CD56(bright) natural killer (NK) cells possess little or no killer immunoglobulin-like receptors (KIRs), high interferon-gamma (IFN-gamma) production, but little cytotoxicity. CD56(dim) NK cells have high KIR expression, produce little IFN-gamma, yet display high cytotoxicity. We hypothesized that, if human NK maturation progresses from a CD56(bright) to a CD56(dim) phenotype, an intermed...

2016
Janine E. Melsen Gertjan Lugthart Arjan C. Lankester Marco W. Schilham

Two human natural killer (NK) cell subsets are usually distinguished, displaying the CD56(dim)CD16(+) and the CD56(bright)CD16(-/+) phenotype. This distinction is based on NK cells present in blood, where the CD56(dim) NK cells predominate. However, CD56(bright) NK cells outnumber CD56(dim) NK cells in the human body due to the fact that they are predominant in peripheral and lymphoid tissues. ...

Journal: :Human reproduction 2011
S M Laird N Mariee L Wei T C Li

BACKGROUND CD56+ cells in peripheral blood or the endometrium may be increased in women with reproductive failure. However, the relationship between numbers of peripheral blood CD56+ and endometrial CD56+ cells is uncertain. The aim of this study was (i) to compare the numbers of CD56+ cells in peripheral blood and endometrium in samples taken simultaneously and (ii) to compare measurements by ...

Journal: :Leukemia & lymphoma 2008
Maria Kraj Urszula Sokołowska Joanna Kopeć-Szlezak Ryszard Pogłód Barbara Kruk Jolanta Woźniak Tomasz Szpila

The aim of this prospective, long-term study was to define the flow cytometric characteristics of plasma cell CD56 expression as well as determine the clinical characteristics of 204 multiple myeloma (MM) patients and 26 plasma cell leukemia (PCL) patients with regard to CD56 expression. CD56 expression intensity was determined by measurement of antigen molecules on the cell defined as Antibodi...

Journal: :Journal of immunology 2009
Daniel S Korbel Paul J Norman Kirsty C Newman Amir Horowitz Ketevan Gendzekhadze Peter Parham Eleanor M Riley

IFN-gamma emanating from NK cells is an important component of innate defense against infection. In this study, we demonstrate that, following in vitro stimulation of human peripheral blood NK cells with a variety of microbial ligands, CD56(dim) as well as CD56(bright) NK cells contribute to the overall NK cell IFN-gamma response with, for most cell donors, IFN-gamma(+) CD56(dim) NK cells outnu...

Journal: :Journal of the Formosan Medical Association = Taiwan yi zhi 2002
Chi-Huang Hsiao Jih-Luh Tang Ming Yao Woei Tsay Chiu-Hwa Wang Yao-Chang Chen Ming-Ching Shen Hwei-Fang Tien

BACKGROUND AND PURPOSE CD56 is a marker of natural killer cells, but can also be found on blast cells in acute myeloid leukemia (AML). The prognostic implications of CD56 expression in AML are not clear. In this study, we evaluated the correlation among CD56 expression, cytogenetic abnormality, and clinical outcome in AML. METHODS CD56 expression was analyzed in leukemic cells from 94 adults ...

2012
Carolina Inés Domaica Mercedes Beatriz Fuertes Ignacio Uriarte María Victoria Girart Jessica Sardañons Dorina Ileana Comas Daniela Di Giovanni María Isabel Gaillard Liliana Bezrodnik Norberto Walter Zwirner

Two populations of human natural killer (NK) cells can be identified in peripheral blood. The majority are CD3(-)CD56(dim) cells while the minority exhibits a CD3(-)CD56(bright) phenotype. In vitro evidence indicates that CD56(bright) cells are precursors of CD56(dim) cells, but in vivo evidence is lacking. Here, we studied NK cells from a patient that suffered from a melanoma and opportunistic...

Journal: :Blood 2007
Stefan Gattenloehner Sergei Chuvpilo Claudia Langebrake Dirk Reinhardt Hans-Konrad Müller-Hermelink Edgar Serfling Angela Vincent Alexander Marx

CD56(high) acute myeloid leukemias (AMLs) have a poor prognosis, but it has been unclear how CD56 expression is controlled and how it relates to clinical aggressiveness. We show that CD56 expression on AML cells correlates with an abnormal expression pattern of runt-related transcription factor 1 (RUNX1) isoforms. Whereas full-length p48 RUNX1 (p48) up-regulated CD56 in AML cells, 3 previously ...

Journal: :Human immunology 2006
Jane Kelly-Rogers Laura Madrigal-Estebas Tony O'Connor Derek G Doherty

A subset of human T lymphocytes expresses the natural killer (NK) cell-associated receptor CD56 and is capable of major histocompatibility complex (MHC)-unrestricted cytotoxicity against a variety of autologous and allogeneic tumor cells. CD56+ T cells have shown potential for immunotherapy as antitumor cytotoxic effectors, but their capacity to control adaptive immune responses via cytokine se...

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