Recent studies have shown that intracerebroventricular administration of cimetidine (CIM) induces anti-nociceptive and anti–inflammatory effects in rats. However, the underlying mechanism of CIM effect has not been determined yet. This study was planned to determine the anti-nociceptive effect of CIM (50 mg/kg, i.p.) in male mice (25-30 g, n = 80) using tail flick test. Also, the role of ATP-se...

........................................................................................................................................................ 4 35 Foreword ....................................................................................................................................................... 5 36 Executive summary ..........................................................

First, we are pleased to announce the launch of the new CIM Series in Mathematical Sciences to be published by Springer-Verlag. The birth of the CIM Series occurred during a meeting between the Executive Board of CIM and the Springer-Verlag Executive Editor Mathematics Martin Peters who honored us with a visit to CIM. The CIM Series will contain proceedings of CIM events, consisting of exposito...

We present the operational principle of a coherent Ising machine (CIM) based on a degenerate optical parametric oscillator (DOPO) network. A quantum theory of CIM is formulated, and the computational ability of CIM is evaluated by numerical simulation based on c-number stochastic differential equations. We also discuss the advanced CIM with quantum measurement-feedback control and various probl...

Negative-pressure wound therapy is routinely utilized in plastic surgery for the treatment of open wounds. However, a newer system, known as closed-incision management (CIM), may minimize the likelihood of open wounds. CIM is designed for use after primary surgical skin closure. Many studies of the effects of CIM in various surgical disciplines have been published. The main features of CIM are ...

........................................................................................................................................................ 4 33 Foreword ....................................................................................................................................................... 5 34 Acknowledgments ............................................................

The research work comprising genetic studies for oil, fatty acid profile, seed cotton yield and lint percentage in eight parental lines (SLH-284, CIM-446, CIM-473, CIM-496, CIM-499, CIM-506, CIM-554, CIM-707) and their F3 populations was carried out during 2011 and 2012 at The University of Agriculture, Peshawar and Nuclear Institute for Food and Agriculture, Peshawar Pakistan. The genetic pote...

BACKGROUND Critical illness myopathy (CIM) and polyneuropathy (CIP), alone or in combination (CIP/CIM), are frequent complications in patients in the intensive care unit (ICU). There is no evidence that differentiating between CIP and CIM has any impact on patient prognosis. METHODS 1-year prospective cohort study of patients developing CIP, CIM or combined CIP and CIM during ICU stay. RESU...

The foundation of Model Driven Architecture (MDA) approach is creation of models. MDA life cycle begins from Computation Independent Model (CIM) and ends with code. Object Management Group (OMG) explains various models and their relations, but it does not specify clearly how to create these models and which models to use for representation them. In this paper, we focus on CIM level. CIM is the ...

This issue marks the last edition of Clinical and Investigative Medicine under the leadership of Dr. David Bevan. Dr. Bevan has been the Editor-in-Chief of CIM for the past six years. During this time, CIM, as the official journal of the Canadian Society for Clinical Investigation, underwent several major changes. First, CIM was bought from the CMA and is now independently produced. Second, CIM...