Metaphors used to describe new technologies mediate public understanding of the innovations. Analyzing the linguistic, rhetorical, and affective aspects of these metaphors opens the range of issues available for bioethical scrutiny and increases public accountability. This article shows how such a multidisciplinary approach can be useful by looking at a set of texts about one issue, the use of ...

Lhx1 encodes a LIM homeobox transcription factor that is expressed in the primitive streak, mesoderm and anterior mesendoderm of the mouse embryo. Using a conditional Lhx1 flox mutation and three different Cre deleters, we demonstrated that LHX1 is required in the anterior mesendoderm, but not in the mesoderm, for formation of the head. LHX1 enables the morphogenetic movement of cells that acco...

On February 15, 2017, the United States Patent and Trademark Office’s Patent Trial and Appeal Board announced its long-awaited decision finding no interference-in-fact between patents and patent applications directed to CRISPR-Cas9 owned by Broad Institute, Inc. et al. and patent applications owned by Regents of the University of California et al. The decision found that the CRISPR-Cas9 gene-ed...

The innovation of CRISPR-Cas9 has single-handedly revolutionized biotechnology by enabling efficient and specific cutting DNA. approaches are promising not only to targetthe human genome but also DNA pathogenic viruses, which coincidentally is the canonical function in its bacterial origin. Since 2014, a myriad studies proven efficacy treatment cleave viral intermediates vitro. One most widely ...

From recombinant insulin to monoclonal antibodies, proteins have become essential drugs in the therapeutic arsenal and respond a broad spectrum of diseases. While commercially available an extracellular activity, intracellular targets can be powerful alternative treat many pathologies such as cancers immune disorders, but also infectious Nevertheless, enter cell reach target organelle or molecu...

Thalassemia is one of the most common genetic disorders, worldwide.Beta-Thalassemia Major (BTM) is the most severe type, which reduces lifeexpectancy and quality of life. In this study, we searched the related keywords to subject from 1996-2019 in the Medline and Web of Science databases, therefore found 250 articles. Moreover, we categorized them into the studies on blood transfusions in...

Circulation. 2017;136:2083–2084. DOI: 10.1161/CIRCULATIONAHA.117.032246 November 21, 2017 2083 Although much of the promise of CRISPR-Cas9 gene editing techniques has centered around correcting disease-causing gene mutations, the advance is also showing potential in the field of xenotransplantation, for example, for making porcine organs safe for transplantation into humans. In an important ste...

Age related macular degeneration (AMD) is a complex retinal disorder, which progressively affects central vision in 4% of the population over 60 (1,2). AMD is caused by multiple environmental and genetic risk factors. Most importantly, smoking as well as genetic variants in the CFH gene (chrom. 1) and the ARMS2/HTRA1 locus (chrom. 10) contribute to the disease pathogenesis. Molecular modeling a...