INTRODUCTION AND OBJECTIVES Calcifying nanoparticles, also known as "nanobacteria," are very small bacteria-like structures (0.1-0.5 μm) with the ability to facilitate the precipitation and growth of calcium phosphate in pathological conditions and have been associated with aortic valve calcification. The status of nanobacteria is controversial; some have proposed that they are a new class of l...

BACKGROUND The purpose of this study was to examine the possible contribution of calcifying nanoparticles to the pathogenesis of placental calcification. METHODS Calcified placental tissues and distal tissue samples were collected from 36 confirmed placental calcification cases. In addition, 20 normal placental tissue samples were obtained as a control group. All the tissue samples were cultu...

Encrusted cystitis is a subtype of chronic cystitis characterized by multiple calcifications in the form of plaques located in the interstitium of the urinary bladder mucosa and frequently associated with mucosal ulcers. It is a very rare disease of controversial etiology. Our transmission electron microscopy of the calcified plaques of encrusted cystitis has revealed that the smallest formed p...

1 Division of Experimental and Clinical Cardiology, Research Institute for Complex Issues of Cardiovascular Diseases under the Siberian Branch of the Russian Academy of Medical Sciences, Kemerovo, Russia 2 Department of Epidemiology, Kemerovo State Medical Academy, Kemerovo, Russia 3 Central Research Laboratory, Kemerovo State Medical Academy, Kemerovo, Russia 4 Department of Oncology, Cancer R...

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Background & Aims: Calcifying nanoparticles are different forms of calcium and phosphate in sediments. Recent evidence suggests that calcifying nanoparticles (CNPs) are probably selfreplicating. Several diseases are linked to nano-bacteria including kidney stones, gallbladder stone, cardiovascular plaques, oral–dental plaque, many cancers, and autoimmune diseases. The aim of this study was to a...

Calcifying nanoparticles (CNPs) (nanobacteria, nanobacteria-like particles, nanobes) were discovered over 25 years ago; nevertheless, their nature is still obscure. To date, nobody has been successful in credibly determining whether they are the smallest self-replicating life form on Earth, or whether they represent mineralo-protein complexes without any relation to living organisms. Proponents...