objective(s): as heat, pain is one of the most common clinical symptoms. generally, calcitonin (ct) is prescribed as an analgesic agent for the treatment of pain, especially for the pain caused by osteoporosis or primary and metastatic bone tumor. however, the detailed mechanism remains unknown.materials and methods: in this study, chronic constriction injury (cci) rat model was created, and ho...

This receptor family comprises a group of receptors for the calcitonin/CGRP peptides. The calcitonin (CT), amylin (AMY), gene-related peptide (CGRP) and adrenomedullin (AM) (nomenclature as agreed by NC-IUPHAR Subcommittee on CGRP, AM, AMY, CT [131, 74, 71]) are generated genes CALCR (which codes receptor, CTR) CALCRL receptor-like CLR, previously known CRLR). Their function pharmacology altere...

Although a strong correlation between neuroendocrine differentiation and angiogenesis of prostate cancer has been reported, no mechanistic link between the two events has been established. Because neuropeptide calcitonin is secreted by prostate tumors and endothelial cells are known to express calcitonin receptor-like receptor, we examined the potential action of calcitonin on endothelial cells...

Calcitonin gene-related peptide receptor antagonists are effective acute migraine treatments without the vascular contraindications associated with triptans. While it has been demonstrated that calcitonin gene-related peptide receptor antagonists act in the central nervous system, their effects in preclinical migraine models have been investigated in only the trigeminocervical complex. Migraine...

243 Introduction 474 Discussion 1165 Non standard abbreviations: AMY, amylin receptor phenotype; CGRP, calcitonin gene-related peptide; CLR, calcitonin receptor-like receptor; CT, calcitonin; CTR, calcitonin receptor; GPCR, G protein-coupled receptor; HA, haemagglutinin epitope tag; hCT, human calcitonin; RAMP, receptor activity modifying protein; rAmy, rat amylin; sCT, salmon calcitonin; TMD, ...

Objective(s): As heat, pain is one of the most common clinical symptoms. Generally, calcitonin (CT) is prescribed as an analgesic agent for the treatment of pain, especially for the pain caused by osteoporosis or primary and metastatic bone tumor. However, the detailed mechanism remains unknown.Materials and Methods: In this study, chronic constriction injury (CCI) rat model was created, and ho...

Calcitonin, a neuroendocrine peptide, and its receptor are localized in the basal epithelium of benign prostate but in the secretory epithelium of malignant prostates. The abundance of calcitonin and calcitonin receptor mRNA displays positive correlation with the Gleason grade of primary prostate cancers. Moreover, calcitonin increases tumorigenicity and invasiveness of multiple prostate cancer...

Two isoforms of the calcitonin receptor are expressed in rabbit: the common C1a isoform and the calcitonin receptor Delta e13 isoform, which has a deletion in the seventh transmembrane domain. Using microphysiometry, we investigated the effects of calcitonin on proton efflux from HEK293 cells stably transfected with C1a, calcitonin receptor Delta e13, or empty vector. In C1a-expressing cells on...

The calcitonin family of peptides comprises calcitonin, amylin, two calcitonin gene-related peptides (CGRPs), and adrenomedullin. The first calcitonin receptor was cloned in 1991. Its pharmacology is complicated by the existence of several splice variants. The receptors for the other members the family are made up of subunits. The calcitonin-like receptor (CL receptor) requires a single transme...