breast cancer is the most important and prevalent cancer in women that can be managed if detected in the early stages. recently, there has been much focus on the use of epigenetic changes such as dna methylation in early detection of cancer. as recent research has put forth dok7 cpg island methylation as an epimarker, in the present study, using a quantification method, a cohort of iranian spor...

introduction raman spectroscopy is a vibrational spectroscopic technique, based on inelastic scattering of monochromatic light. this technique can provide valuable information about biomolecular changes, associated with neoplastic transformation. the purpose of this study was to find raman spectral markers for distinguishing normal samples from cancerous ones in different tissues. materials and...

breast cancer (bc) accounts for one of the major health problems around the world. since the diagnosis process can have great effect on therapy outcomes, we studied the biomarkers specific to breast tumors stage i based on examining different iranian patients. cases from different stages were examined to discover their highly expressed proteins. in addition, pathologic evaluations were performe...

cancer, with a high rate of mortalities worldwide, pose a major threat to human health. although family history accounts for at least 5-10% of all cancers, it is conferred to be as a significant risk of developing cancer. recently, application of high speed and low cost high-throughput nucleotide sequencing technologies has provided an opportunity to assess cancer risk in at risk healthy indivi...

objective(s): breast cancer is the most common cancer in women. every year, one million new cases are reported worldwide, representing 18% of the total number of cancer in women. hereditary brca1 and brca2 mutations account for about 60% of inherited breast cancer and are the only known causes of hereditary breast cancer syndrome. the aim of this study was to determine the frequency of brca2 (e...

introduction: several radiotracers are being used for sentinel node mapping in patients with breast cancer. in the current study, we reported our experience with 99m-tc phytate for sentinel node mapping in mashhad university of medical sciences. methods: all breast cancer patients who underwent sentinel node mapping using 99m-tc phytate were included. all patients received intradermal peri-areo...

background: early diagnosis and endoscopic resection of adenomatous polyps is the main approach for screening and prevention of colorectal cancer (crc). we aimed to assess polyp detection rate (pdr) and to characterize demographic, clinical, and pathological features of colorectal polyps in an iranian population. methods: we retrospectively analyzed the data from 5427 colonoscopies performed du...

background: an early diagnosis of breast cancer relates directly to an accurate treatment plan and strategy. early detection of breast cancer before its development would be a significant reduction of morbidity and mortality rates. the aim of this preliminary study is to investigate the sensitivity of wide angle x-ray diffraction (waxrd) method on women hair samples of healthy and breast cancer...

background colorectal cancer (crc) is the third most common cancer in iran and its early detection is necessary. this study is based on perception of people in the east of iran toward crc screening.   methods in a cross-sectional study, 1060 randomly selected individuals who referred to razavi hospital of mashhad, iran, between september the 1st, 2012 and february the 28th, 2013 as patients or ...

abstract background: many disease susceptibility genes are large and consist of many exons in which point mutations are scattered throughout. scanning each exon individually represents a tedious task which can be time consuming and expensive. there has been increasing demand for rapid and accurate methods for full scanning of unknown point mutations in large multi-exon genes. gene assembling is...