Abstract Geroprotectors are drugs that decrease the rate of aging and therefore extend life span. Metformin has been described as a geroprotector, and several studies have shown that metformin can slow down the rate of aging. The mechanisms behind the geroprotective effect of metformin are less established. The goal of this review is to investigate the evidence for the geroprotective effect o...

Introduction . Fucoxanthin is one of the main representatives marine carotenoids with a wide range biological activities, including geroprotective effect. The most common source fucoxanthin in food industry diatomic algae (e.g., Phaeodactylum tricornutum). aim work was to summarize and analyze data on mechanisms action fucoxanthin. Materials Methods An analysis scientific research publications ...

It is well documented that life expectancy in developed countries at birth is going to increase from the 20th century. However, regrettably, a potential decline in life expectancy has been proposed for these nations in the 21st century due to a rapid upsurge in the prevalence of fatal degenerative diseases like cardiovascular diseases (CVD), cancer and diabetes. Collectively, these three diseas...

Flavonoids is an intensively studied group of natural compounds with antioxidant, antineoplastic, antihyperglycemic, cardioprotective, and neuroprotective properties. The present study intends to investigate the geroprotective action of three selected flavonoids (naringin, luteolin, chrysin) in two model organisms, Caenorhabditis elegans and Drosophila melanogaster. Luteolin and chrysin were sh...

Hyperbaric oxygenation therapy (HBOT) has been gaining an increasing recognition as a versatile therapeutic approach. This article reviews the application of hyperbaric oxygenation as a method for resuscitation and therapy of elderly patients with cerebral and cardio-respiratory dysfunction, in acute as compared to chronic impairments. The vital role of proper dosage of HBO therapy to ensure bo...

Novel mechanism of antioxidant activity of buckminsterfullerene C₆₀ based on protons absorbing and mild uncoupling of mitochondrial respiration and phosphorylation was postulated. In the present study we confirm this hypothesis using computer modeling based on Density Functional Theory. Fullerene's geroprotective activity is sufficiently higher than those of the most powerful reactive oxygen sp...

This systematic review investigated whether the insulin sensitiser metformin has a geroprotective effect in humans. Pubmed and Embase were searched along with databases of unpublished studies. Eligible research investigated the effect of metformin on all-cause mortality or diseases of ageing relative to non-diabetic populations or diabetics receiving other therapies with adjustment for disease ...

background: gastric and colorectal adenocarcinoma are the second and the fifth most common cancers in iran, respectively. expression of cytokeratin 7 (ck7) is established in most malignancies including gastric and colorectal adenocarcinoma. demonstration of ck7 could be related to prognostic factors and help to the better management of the patients. the objective of our study was to evaluate th...