Amorphous films of the anticonvulsant drug carbamazepine are easily accessible by various methods, while the crystallization into specific polymorphs represents a challenging and time-consuming task. In this work, the crystallization of drop cast carbamazepine at silica surfaces is investigated by atomic force microscopy and both in situ and ex situ grazing incidence X-ray diffraction. The pris...

in order to improve particle properties, new processes combining granulation and crystallization are being developed. this work deals with the spherical crystallization process by the quasi-emulsion mechanism applied to carbamazepine, a pharmaceutical drug. the aim of the present study was to produce of spherical grains made of mall crystals of a drug that have adequate properties for direct co...

The morphology of crystals has an appreciable impact role on the physicochemical properties of drugs. Drug properties such as flowability, dissolution, hardness and bioavailability may be affected by crystallinity behaviours of drugs. The objective of this study was to achieve an improved physicomechanical property of carbamazepine powder through recrystallization from aqueous solutions at diff...

In order to improve particle properties, new processes combining granulation and crystallization are being developed. This work deals with the spherical crystallization process by the quasi-emulsion mechanism applied to carbamazepine, a pharmaceutical drug. The aim of the present study was to produce of spherical grains made of mall crystals of a drug that have adequate properties for direct co...

In order to improve particle properties, new processes combining granulation and crystallization are being developed. This work deals with the spherical crystallization process by the quasi-emulsion mechanism applied to carbamazepine, a pharmaceutical drug. The aim of the present study was to produce of spherical grains made of mall crystals of a drug that have adequate properties for direct co...

Co-crystallization brings new opportunities for improving the solubility and dissolution rate of drugs with the chance of finely tuning some relevant chemical-physical properties of mixtures containing bioactive compounds. As co-crystallization process involves several molecular species, which are generally solid at room conditions, its control requires accurate knowledge and monitoring of the ...

We describe a microfluidic approach to optimize crystallization of active pharmaceutical ingredients (APIs) and their solid forms (cocrystals) via crystal seeding. Subsequent on-chip X-ray diffraction is used to verify the crystal from. The microfluidic platform comprises an 8 × 9 well array that enables screening of seeding conditions (dilutions) by metering of API solution or API/cocrystal fo...

We describe the use of low-molecular-weight supramolecular gels as media for the growth of molecular crystals. Growth of a range of crystals of organic compounds, including pharmaceuticals, was achieved in bis(urea) gels. Low-molecular-weight supramolecular gelators allow access to an unlimited range of solvent systems, in contrast to conventional aqueous gels such as gelatin and agarose. A det...