OBJECTIVE Glass carbomer cement represents a new generation of dental material, which mineralizes gradually into fluorapatite. The aim of this study was to evaluate the microleakage and marginal integrity of newly developed glass carbomer cement with and without protective surface coating (SC) in primary molars. METHODS Standardized cavities were prepared on extracted human primary molars, an...

Glass Carbomer is a new generation of restorative material developed from glass-ionomer cements with possibility of gradual mineralization into fluorapatite. The aim of this clinical trial was to investigate the retention of Glass Carbomer fissure sealant after 12 months, in comparison to a commonly used conventional resin-based sealant. Forty-eight teeth in 24 patients [mean (SD) = 8 (2.3) yea...

Carbomer gel was prepared with 300mM D-sorbitol (Sigma-Aldrich, St. Louis, MO) and 10mM HEPES free acid (Sigma-Aldrich, St. Louis, MO) in heated distilled water. A gelling agent, carbomer 940 (Snowdrift Farm, Tucson, AZ), was added to the heated sorbitol solution under constant stirring, to reach a concentration of 0.3%, based on a weight percent. Once the carbomer was completely dissolved in t...

PURPOSE To compare the efficacy, safety, and local tolerance between carbomer-based artificial tears, cellulose-, and mineral oil-based artificial tears. METHODS A randomized, open-label, parallel-group comparative 28-day study was designed for 67 patients who were randomized into three treatment groups. Measurements included the scoring of total subjective symptoms and objective signs, Schir...

Interaction of the antipsychotic drug risperidone with hydroxypropyl-beta-cyclodextrin (HPBCD) in solution and in the solid state was studied with the aim of overcoming the limitations associated with nasal administration of low solubility drugs. Risperidone solubility studies revealed inclusion complex formation with a 1:1 stoichiometry. Low concentrations (0.1 w/v %) of hydroxypropylmethyl ce...

OBJECTIVES The purpose of this study was to characterize commercial glass polyalkenoate cement (GPC) or glass ionomer cement (GIC), Glass Carbomer(®), which is designed to promote remineralization to fluorapatite (FAp) in the mouth. The setting reaction of the cement was followed using magic angle spinning nuclear magnetic resonance (MAS-NMR) spectroscopy. METHODS Glass Carbomer(®) initial gl...

background the goal of the present study was the preparation and evaluation of griseofulvin topical gel as a drug dosage form with appropriate efficacy and stability. material and methods to select the best formulation, formulations with different concentration of carbomer and hpmc were evaluated for their appearance. then evaluated for physicochemical characteristics such as rheologic behavior...

Previous reports show ineffective transdermal delivery of ketorolac by nanostructured lipid carriers (NLCs). The aim of the present work was enhancement of transdermal delivery of ketorolac by another colloidal carriers, lipid nanocapsules (LNCs). LNCs were prepared by emulsification with phase transition method and mixed in a Carbomer 934P gel base with oleic acid or propylene glycol as penetr...

Using a strain-controlled rheometer, rhelogical characterization of carbopol 940 has been made in steady shear and start-up flow fields. In this study, aqueous carbopol 940 solutions with different concentrations were used to provide a fundamental information in application of pharmaceutical and cosmetic areas.

Background: The stratum corneum (SC) forms a difficult physical barrier for drugs to pass through the skin. Several strategies were developed to overcome this barrier. Optimization of topical drug formulations by selected excipients may facilitate the penetration of drugs through the SC into the viable skin cells and ultimately into the systemic circulation. Methods: Here, both the influence of...