Chitosan was prepared from crab shell. Different derivatives of chitosan e.g. phosphate, cyanoethyl and carboxymethyl chitosan are prepared. Molecular structure of chitosan and its derivatives was fallowed by infrared spectroscopy. A new band at 1715cm -1 (carboxyl group), at 2253cm -1 (cyano group) and at 1200cm -1 for (c-o-p) in spectra of carboxymethyl chitosan, cyanoethyl chitosan and chito...

OBJECTIVE The study objectives were to assess the efficacy of N,O carboxymethyl chitosan film in reducing postsurgical adhesion in a rabbit cardiac injury model and to confirm the efficacy of N,O carboxymethyl chitosan gel and film in reducing postsurgical adhesion formation in a pig cardiac injury model. METHODS (1) Rabbit cardiac injury model: Cardiac injury was generated by abrading the an...

OBJECTIVE The study objectives were to (1) assess the efficacy of N,O-carboxymethyl chitosan on postsurgical adhesion formation after cardiac surgery using a rabbit cardiac injury model and (2) explore the mechanism of action of N,O-carboxymethyl chitosan in the prevention of postsurgical adhesions using in vitro experimentation. METHODS In the rabbit cardiac injury model, cardiac injury was ...

Carboxymethyl chitosan was prepared by reacting chitosan with chloroacetic acid in water under microwave irradiation. The effect of the reaction conditions was investigated and optimal conditions were identified. The influence of mass ratio of chloroacetic acid to chitosan, microwave power and pH on the degree of substitution or intrinsic viscosity were further studied. The degree of substituti...

Chitosan is a cationic polysaccharide with great properties and so is considered as an attractive biopolymer. However, chitosan shows its antibacterial activity only in acidic environment and this restricts its uses. So water-soluble chitosan derivatives such as carboxymethyl chitosan could be good candidates for such biomedical applications. Modified chitosan with hydrophobic functional groups...

Chitosan and its derivatives have attracted great attention due to their properties beneficial for application to wound healing. The main focus of the present review is to summarize studies involving chitosan and its derivatives, especially N,N,N-trimethyl-chitosan (TMC), N,O-carboxymethyl-chitosan (CMC) and O-carboxymethyl-N,N,N-trimethyl-chitosan (CMTMC), used to accelerate wound healing. Mor...

OBJECTIVES/HYPOTHESIS Silicone voice prostheses are most frequently used in voice rehabilitation of laryngectomized patients. However, the functional device lifetimes are limited due to formation of mixed biofilms. Existing in vitro models simulating biofilm formation are restricted to only short-term periods. STUDY DESIGN The goal of this study was to determine the effect of carboxymethyl ch...

Carboxymethyl-hexanoyl chitosan (NOCHC) amphiphatic hydrogel with excellent water-absorption and water-retention abilities under neutral conditions was successfully synthesized for the first time and then employed as a carrier for delivering amphiphatic agents. NOCHC is a water-soluble chitosan derivative bearing the carboxymethyl (hydrophilic) group and the hexanoyl (hydrophobic) group, which ...

the main objective of the present study is to investigate the feasibility of using carboxymethyl chitosan magnetic nanoparticles (ccmn) for the adsorption of cd2+. the study also reports important parameters, which affect the adsorption process, i.e., ph, adsorbent dose, contact time and concentration of cd2+, using box-behnken designs. firstly, functional carboxymethyl chitosan magnetic nanopa...