Background-Cardiosphere-derived cells (CDCs) are an attractive cell type for tissue

RATIONALE Molecular imaging is useful for longitudinal assessment of engraftment. However, it is not known which factors, other than cell number, can influence the molecular imaging signal obtained from reporter genes. OBJECTIVE The effects of cell dissociation/suspension on cellular bioenergetics and the signal obtained by firefly luciferase and human sodium-iodide symporter labeling of card...

www.thelancet.com Vol 379 June 30, 2012 2425 2 Lemos B, Araripe LO, Hartl DL. Polymorphic Y chromosomes harbor cryptic variation with manifold functional consequences. Science 2008; 319: 91–93. 3 Lemos B, Branco AT, Hartl DL. Epigenetic eff ects of polymorphic Y chromosomes modulate chromatin components, immune response, and sexual confl ict. Proc Natl Acad Sci USA 2010; 107: 15826–31. 4 Spach ...

Cardiovascular diseases remain the leading causes of death worldwide. Stem cell therapy offers a promising option to regenerate injured myocardium. Among the various types of stem cells, cardiosphere cells represent a mixture of intrinsic heart stem cells and supporting cells. The safety and efficacy of cardiosphere cells have been demonstrated in recent clinical trials. Cell-matrix interaction...