One of the goals of medicinal chemistry research and drug discovery is to provide a rationalbasis for the design of new medicinal agents. Organic compounds and their reactions have beenutilized by people since antiquity. Due to the increasing demand for bioactive molecules, organicchemists are increasingly required to synthesize new compounds of biological interest. AsBenzimidazoles are very us...

background and objective: the circle of willis (cow) supports adequate blood supply to the brain. the cardiovascular system, in the current study, is modeled using an equivalent electronic system focusing on the cow. method: in our previous study we used 42 compartments to model whole car- diovascular system. in the current study, nevertheless, we extended our model by using 63 compartments to ...

emergence from general anesthesia can be associated with coughing, agitation, and hemodynamic disturbances. remifentanil may attenuate these responses. we have examined the effect of remifentanil on the hemodynamic response to the emergence from anesthesia and tracheal extubation. in a double-blind, randomized trial, we enrolled 50 adult patients undergoing abdominal surgery. all patients recei...

effects of acute systemic hypoxia on the cardiovascular system (cys) and respiration of spontaneously breathing cats were studied in two conditions. 1): hypoxic air (6-8% 02 in n2) was given to the animal to induce systemic hypoxia for 20 minutes. hyperventilation at this condition lowered arterial c02 tension (pac02 hypocapnia). 2): in the second run, induction of hypocapnia was prevented by a...

background and objectives: most patients experience moderate to severe anxiety before cardiac catheterization. this study aimed to investigate the effect of rosa aromatherapy on anxiety before cardiac catheterization. methods: in this randomized controlled trial, 60 patients who met the inclusion criteria were conveniently sampled and randomly allocated to the experimental and control groups. p...

effects of acute hypercapnia on the cardiovascular system (cys) were studied in the anesthetized cat. after surgery the animal was exposed to a gas mixture of 12% co2 and 25% o2 in nitrogen, and hypercapnia with low levels of arterial ph (pha) was produced for 20 minutes. in the second run the same level of hypercapnia was induced by ventilating the same cat from the above gas mixture but pha w...

background many types of cardiovascular complications such as; cardiac arrhythmias, impaired cardiac function, myocardial ischemia and decreased left ventricular function, have been attributed to interferon therapy. objectives the aim of this study was to evaluate the effects of combination therapy pegylated interferon and ribavirin on left ventricular systolic and diastolic functions in patien...

1024x768 normal 0 false false false en-us x-none ar-sa background and objective: numerical modeling of biological structures would be very helpful tool to analyze hundreds of human body phenomena and also diseases diagnosis. one physiologic phenomenon is blood circulatory system and heart hemodynamic performance that can be simulated by utilizing lumped method. in this study, we can predict hem...