نتایج جستجو برای: Cefotaxime

تعداد نتایج: 2634  

Journal: :Infection 1983
F Kees E Strehl P Dominiak H Grobecker K Seeger G Seidel B Neuhaus L Safrany

In a previous paper we reported on the determination of cefotaxime and desacetyl cefotaxime in human and rat serum after an i.v. injection of this cephalosporin (1); the concentrations of the parent compound and its metabolite in human bile were also briefly described. It has been shown that older cephalosporins with a 3~ acetoxymethyl substituent, e. g. cephalothin, are metabolised to the resp...

Journal: :Antimicrobial agents and chemotherapy 1997
I R Friedland K P Klugman

We determined cefotaxime and desacetyl-cefotaxime concentrations in children with bacterial meningitis receiving high-dose cefotaxime (300 mg/kg of body weight/day) and concomitant dexamethasone therapy. The median peak cerebrospinal fluid cefotaxime and desacetyl-cefotaxime concentrations were 4.7 and 8.1 microg/ml, respectively. In vitro bactericidal activity (>99.9% killing in 6 h) was found...

Journal: :The Clinical Investigator 1993

Journal: :Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics 1996

2014
Hee-Chang Jang Su-Mi Choi Hee Kyung Kim Sung-Eun Kim Seung-Ji Kang Kyung-Hwa Park Phil Youl Ryu Tae-Hoon Lee Young Ran Kim Joon Haeng Rhee Sook-In Jung Hyon E Choy

OBJECTIVES The in vivo efficacy of a cefotaxime-ciprofloxacin combination against Vibrio vulnificus and the effects on rtxA1 expression of commonly used antibiotics are unknown. METHODS In vitro time-kill studies were performed to evaluate synergism. Female BALB/c mice were injected subcutaneously with 1×10(7) or 1×10(8) cfu of V. vulnificus. Antibiotic therapy was initiated at 2 h after inoc...

Journal: :Antimicrobial Agents and Chemotherapy 1979

Journal: :The Journal of antibiotics 1979
K P Fu H C Neu

The beta-lactamase stability and inhibitory activity of 1-oxa cephalosporin, (6R,7R)-7-[[carboxy(4-hydroxyphenyl)acetyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, was investigated and compared to that of cefoxitin and cefotaxime. There was no detectable beta-lactamase hydrolysis of 1-oxa cephalosporin, cefotaxime and ...

Journal: :Antimicrobial agents and chemotherapy 1981
R Wise N Wright P J Wills

The pharmacology of cefotaxime and the metabolite desacetyl cefotaxime was studied in 40 patients with various degrees of renal and hepatic failure who received 0.5 or 1 g of cefotaxime intravenously. Patients with severe renal impairment (creatinine clearance, 3 to 10 ml/min) had a cefotaxime serum half-life of 2.6 h and desacetyl cefotaxime serum half-life of 10.0 h. The equivalent figures we...

2010
CH. Aswani Kumar T. Anil Kumar Rahul Reddy

A new, simple and sensitive spectrophotometric method for the determination of valacyclovir and cefotaxime has been developed. The method is based on the condensation of valacyclovir and cefotaxime with 1, 2napthaquinone-4sulfonic acid sodium (NQS) in alkaline media to yield orange colored products respectively. Valacyclovir and cefotaxime showed maximum absorbance at 495nm and 475nm with linea...

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