purpose: to explore any association between human papilloma virus (hpv) infection and ocular surface squamous neoplasia. methods: forty pathological specimens including 20 cases of conjunctival intra-epithelial neoplasia grade i (cin i) and 20 cases of cin iii and invasive squamous cell carcinoma (scc) together with 20 pterygium samples (controls) were analyzed by polymerase chain reaction (pcr...

Human papillomavirus (HPV)-associated cervical carcinoma is preceded by stages of cervical intra-epithelial neoplasia (CIN) that can variably progress to malignancy. Understanding the different molecular processes involved in the progression of pre-malignant CIN is critical to the development of improved predictive and interventional capabilities. We tested the role of regulators of transcripti...

In order to provide greater insight into both the extensiveness and the medical costs of the diagnosis and treatment of screen-detected cervical intra-epithelial neoplasia (CIN) in general medical practice in The Netherlands, data from national registries and gynaecology departments were retrieved, and experts were interviewed. Of the 5060 women diagnosed with CIN in 1988, more than 50% were tr...

Fifty women attending a clinic for sexually transmitted diseases with vulval condylomata acuminata were examined by cervical cytology and colposcopy for cervical infection by human papillomavirus (HPV) or epithelial abnormality indicating cervical intraepithelial neoplasia (CIN) or both. Collated results showed a high prevalence of both conditions in these 50 women; 25 (50%) had evidence of cer...

Cervical cancer is the leading cancer among Indian women with the estimated age standardized incidence and mortality rates around 2008 of 27 and 15 per 100,000 woman years, respectively (Ferlay et al., 2012). The age standardized cervical cancer incidence rates range from 9-40 per 100,000 woman years in various regions of India (Sankaranarayanan et al., 2008). Persistent infection with specific...

The aim of this study was to compare the diagnostic efficacy colposcopic-directed biopsy and four-quadrant in detecting high-grade cervical intra-epithelial neoplasia (CIN). Women attending three women’s clinics for routine screening were recruited. Colposcopy arranged women with any cytologic abnormalities greater than atypical squamous cells undetermined significance (ASCUS), two consecutive ...

Background: Cervical intraepithelial neoplasia (CIN) is a premalignant lesion capable of progressing to cervical cancer. Despite the existing well-defined criteria, the histomorphologic diagnosis is subject to high rates of discordance among pathologists. The aim of this study was to evaluate Ki-67 (MIB-1), CK17 and p16 INK4a (p16) markers by immunohistochemical methods in differentiating CIN f...

Background: In Bangladesh, loop electrosurgical excision procedure (LEEP) is an ongoing program of government health service for the management cervical intra-epithelial neoplasia (CIN) 2 and 3. The aim this study was to evaluate outcome following treatment Methods: This descriptive cross-sectional conducted in outpatient department (OPD), gynaecology obstetrics department, Rangpur Medical Coll...

Background and Objective: The currentstudy aimed at investigating the histomorphological spectrum of cervical intraepithelial and invasive lesions assessing the diagnostic significance of P16/INK4a and Ki-67 in such lesions, andcorrelatingP16/INK4a and Ki-67 immunoexpression with histologic type and grade.Methods: A total of 60 cases were selectedcomprisi...