Almost 50 years ago, Munk and Rosenstein (1) reported the feeding of cetyl palmitate, as spermaceti, to a patient suffering from a chronic chyle fistula. Whereas they could recover a good portion of the palmitic acid, as tripahnitin, from the chyle, they were unable to demonstrate the presence of any cetyl alcohol in this material. It has since been shown by Mancke (2) that, even when large amo...

Controlled release (CR) Ciprofloxacin (CFX) matrix tablets were prepared using Ciprofloxacin betaine as a model drug and Kollidon SR as a core matrix former. Kollidon SR embedded CFX matrix tablets were then characterized with Carbopol 974P NF, Cetyl alcohol, Hydroxypropyl methyl cellulose (HPMC 4.5 cps). CFX release was 74% after 10 hours dissolution in 0.01 N HCl solution from the tablets con...

1. The isolated stomachs of the dogfish, Squdus acanthias, and the skate, Raja erinacea, were found to incorporate long chain alcohols and acetate, but not long chain fatty acids, into glyceryl ethers. 2. The criterion for evaluation of incorporation of radioactive substrates into glyceryl ethers was the measurement of activity of individual isopropylidene derivatives separated by means of gas-...

The present study was aimed towards the formulation and in vitro evaluation of orodispersible tablets by direct compression method using Risperidone as a model drug to enhance patient compliance. Orodispersible tablet of Risperidone was prepared by masking the bitter taste by cetyl alcohol using different ratios of drug with cetyl alcohol (2:1). Here crosspovidone and sodium starch glycolate in...

Hydrophobically modified ethoxylated urethanes have been synthesized using polyethylene glycol, hexamethylene diisocyanate and cetyl alcohol. These types of thickeners are categorized as nonionic associative thickeners. The HEURs were prepared in two steps. Initially an ethoxylated urethane prepolymer was synthesized through a reaction between a polyethylene glycol (Mn=6000) and hexamethylene d...

effects of formulation parameters on the fractional release profile of diclofenac sodium from matrices having the manufacturing formulation ingredients are studied. as a content of cetyl alcohol (rate controlling agent) in the matrix increases, the fractional release decreases. the fractional release increases either by increasing sucrose content outside the granule or by decreasing sucrose con...

Guaifenesin, a highly water-soluble active (50 mg/mL), classified as a BCS class I drug.Owing to its poor flowability and compressibility, formulating tablets especially high-dose one,may be a challenge. Direct compression may not be feasible. Bilayer tablet technology appliedto Mucinex®, endures challenges to deliver a robust formulation. To overcome challengesinvolved in bilayer-tablet manufa...

Guaifenesin, a highly water-soluble active (50 mg/mL), classified as a BCS class I drug.Owing to its poor flowability and compressibility, formulating tablets especially high-dose one,may be a challenge. Direct compression may not be feasible. Bilayer tablet technology appliedto Mucinex®, endures challenges to deliver a robust formulation. To overcome challengesinvolved in bilayer-tablet manufa...