Ten men with bubo associated with chancroid were studied for bacterial flora especially anaerobes. Anaerobes were isolated from all 10 buboes and eight out of 10 ulcers of chancroid. Anaerobic cocci, B melaninogenicus and B fragilis were the most common isolates. anaerobes probably play a role in the pathogenesis of bubo in chancroid.

A randomized, double-blind, placebo-controlled clinical trial was conducted in Nairobi, Kenya, to compare single-dose ciprofloxacin with a 7-day course of erythromycin for the treatment of chancroid. In all, 208 men and 37 women presenting with genital ulcers clinically compatible with chancroid were enrolled. Ulcer etiology was determined using culture techniques for chancroid, serology for sy...

Chancroid is a highly infectious and curable sexually transmitted disease caused by the bacterium Haemophilus Ducreyl (also known as H. Ducreyl). A deterministic mathematical model for investigating the role of treatment on controlling chancroid epidemic is formulated and rigorously analyzed. A threshold quantity known as the productive number, which measures the number of secondary infections ...

Genital ulcers are important cofactors of HIV transmission in the countries most severely affected by HIV/ AIDS. Chancroid is a common cause of genital ulcer in all 18 countries where adult HIV prevalence surpasses 8% and is rare in countries with low-level HIV epidemics. Haemophilus ducreyi, the causative organism of chancroid, is biologically vulnerable and occupies a precarious epidemiologic...

THE true incidence of chancroid throughout Africa is unknown, although it is apparent that it is the venereal disease next in importance to syphilis and gonorrhrea, in some places being more prevalent than primary syphilis. Although chancroid is not capable of arresting the development of whole populations, as are gonorrhrea and syphilis by causing sterility and abortion, and although it has no...

The etiologic agent of chancroid is Haemophilus ducreyi. To fulfill its obligate requirement for heme, H. ducreyi uses two TonB-dependent receptors: the hemoglobin receptor (HgbA) and a receptor for free heme (TdhA). Expression of HgbA is necessary for H. ducreyi to survive and initiate disease in a human model of chancroid. In this study, we used a swine model of H. ducreyi infection to demons...