transfusion in the treatment of thalassemia gives rise to iron deposits in many organs. since there are many obstacles in the use of deferoxamin (dfo) as an iron chelating agent, it is important to find another alternative therapy that can act as iron chelation. the study aims to compare the histopathological pictures of the heart and spleen in iron-induced rats after administration of dfo and ...

transfusion-dependent patients such as those suffering from β-thalassaemia develop a fatal secondary haemosiderosis and consequently a selective iron chelator must be used to relieve such iron overload. 3- hydroxypyridin-4-ones are selective for iron(iii) under most biological conditions, but unlike desferrioxamine, are efficiently absorbed when administered orally. in this study, the synthesis...

iron overload is a serious clinical condition which can be largely prevented by the use of iron-specific chelating agents. in this study, the synthesis and determination of partition coefficients (kpart) of a range of n-alkyl hydroxypyridinones, as orally active iron chelators, are described. synthesis of n-aryl hydroxypyridinones was achieved via a single step synthetic pathway. in this method...

a 19-year-old woman was referred to the emergency surgery department with severe abdominal pain, icterus, and anemia. the patient’s clinical and paraclinical findings in addition to her occupational and social history, convinced us to assay blood lead level (bll), which was 41/5 µg/dl. therefore toxicology consult was performed to treat lead toxicity. recheck of the bll showed the level as 53/7...

The structures of europium–EDTA (known lanthanide chelator) and europium–nicotianamine (biochemical precursor phytosiderophores) complexes are resolved, in solution, with ab initio molecular dynamics as well excitation emission spectroscopy.

Current iron chelation therapy consists primarily of DFO (desferrioxamine), which has to be administered via intravenous infusion, together with deferiprone and deferasirox, which are orally-active chelators. These chelators, although effective at decreasing the iron load, are associated with a number of side effects. Grady suggested that the combined administration of a smaller bidentate chela...

objectives: iron chelators, such as maltol and kojic acid, have antioxidant and anti-inflammatory properties. they may have beneficial effects on inflammatory bowel disease (ibd) because iron can develop and aggravate inflammation in ibd. in the present study, the effect of selected iron chelators and anti-oxidants were evaluated on a model of trinitrobenzene sulfonic acid (tnbs)-induced coliti...