Chitosan is a versatile natural polymer. This article reviewed different aspects of Chitosan that’s including preparation and characterization of Chitosan with their applicability in pharmaceutical formulations. Also, the article included different derivatives of Chitosan and their use in different drug delivery system. This review emphasized that research on Chitosan based systems containing v...
:Journal of biomedical materials research. Part A2006
Jason A Burdick,
Christopher B Highley,
Daniel S Kohane,
The suitability of chitosan and UV-cross-linkable chitosan for intraperitoneal use, for example as a barrier device for preventing peritoneal adhesions or for drug delivery, was examined. In vitro experiments using two major cell types present in the peritoneal cavity (mesothelial cells and peritoneal macrophages) revealed neither attractive interactions between cross-linked chitosan gels and t...
Anne des Rieux,
Chitosan is a nontoxic, biodegradable, and biocompatible polysaccharide of b(1-4)-linked D-glucosamine and N-acetyl-D-glucosamine. This derivative of natural chitin presents remarkable properties that have paved the way for the introduction of chitosan in the biomedical and pharmaceutical fields. Nevertheless, the properties of chitosan, such as its poor solubility in water or in organic solven...
Ligia L. Fernandes,
Cristiane X. Resende,
Débora S. Tavares,
Gloria A. Soares,
Letícia O. Castro,
Jose M. Granjeiro,
In this work, chitosan and collagen-chitosan porous scaffolds were produced by the freeze drying method and characterized as potential skin substitutes. Their beneficial effects on soft tissues justify the choice of both collagen and chitosan. Samples were characterized using scanning electron microscope, Fourier Transform InfraRed Spectroscopy (FTIR) and thermogravimetry (TG). The in vitro cyt...
Abdelbasset El Hadrami,
Lorne R. Adam,
Ismail El Hadrami,
Chitin and chitosan are naturally-occurring compounds that have potential in agriculture with regard to controlling plant diseases. These molecules were shown to display toxicity and inhibit fungal growth and development. They were reported to be active against viruses, bacteria and other pests. Fragments from chitin and chitosan are known to have eliciting activities leading to a variety of de...
William E Bentley,
Gary W Rubloff,
James N Culver,
Gregory F Payne,
The traditional motivation for integrating biological components into microfabricated devices has been to create biosensors that meld the molecular recognition capabilities of biology with the signal processing capabilities of electronic devices. However, a different motivation is emerging; biological components are being explored to radically change how fabrication is achieved at the micro- an...
Aliasger K. Salem,
Maureen D. Donovan,
Chitosan, a copolymer of glucosamine and N-acetyl glucosamine, is a polycationic, biocompatible and biodegradable polymer. In addition, chitosan has different functional groups that can be modified with a wide array of ligands. Because of its unique physicochemical properties, chitosan has great potential in a range of biomedical applications, including tissue engineering, non-viral gene delive...
In the past 20 years, there has been a growing trend towards the development and use of biomaterials for the repairing and restoration of damaged bone tissue. The calcium phosphate bioceramics have attracted great attention in the field of orthopaedics because of its similarity to the mineral component of bone tissue. They have been used as granules for example in non-load bearing small implant...
Victoria Tamara Perchyonok,
Sias R. Grobler,
Theunis G. Oberholzer,
The purpose of the study was to design and evaluate novel functional chitosan hydrogels (chitosan-H-propolis, chitosan-H-propolis-nystatin and chitosan-H-nystatin) by using the chitosan-H polymer as "dual function restorative materials".
MATERIALS AND METHODS
The nystatin/antioxidant carrier gel was prepared by dispersion of the corresponding component in glycerol and 3% acetic acid...
:Drug design, development and therapy2016
Tarek A Ahmed,
Bader M Aljaeid,
Naturally occurring polymers, particularly of the polysaccharide type, have been used pharmaceutically for the delivery of a wide variety of therapeutic agents. Chitosan, the second abundant naturally occurring polysaccharide next to cellulose, is a biocompatible and biodegradable mucoadhesive polymer that has been extensively used in the preparation of micro-as well as nanoparticles. The prepa...