Chitosan is widely used in the biomedical field due its chemical and pharmacological properties. However, intake of chitosan results in renal tissue accumulation of chitosan and promotes an increase in calcium excretion. On the other hand, the effect of chitosan on the formation of calcium oxalate crystals (CaOx) has not been described. In this work, we evaluated the antioxidant capacity of chi...

Chitosan, a given name to a deacetylated form of chitin, is a natural biodegradable compound derived from crustaceous shells such as crabs and shrimps, whose main attributes corresponds to its polycationic nature. Chitosan has been proven to control numerous pre and postharvest diseases on various horticultural commodities. It has been reported that both soil and foliar plant pathogens fungal, ...

Hybrid nanofibrous membranes of poly(lactic-co-glycolic acid) (PLGA) and chitosan with different chitosan amounts (32.3, 62.7, and 86.5%) were fabricated via a specially designed electrospinning setup consisting of two sets of separate syringe pumps and power supplies. After soaking in chloroform overnight to dissolve PLGA, the amount of chitosan in the hybrid membranes was determined. The stru...

Mucoadhesive drug therapy destined for localized drug treatment is gaining increasing importance in today's drug development. Chitosan, due to its known biodegradability, bioadhesiveness and excellent safety profile offers means to improve mucosal drug therapy. We have used chitosan as mucoadhesive polymer to develop liposomes able to ensure prolonged residence time at vaginal site. Two types o...

The objective of this study was to investigate the effects of a copper loaded chitosan scaffold on bone regeneration in critical-sized calvarial defects in rats. Chitosan scaffolds and copper-chitosan scaffolds were fabricated and characterized by scanning electron microscopy (SEM). Chitosan and copper-chitosan scaffolds were implanted into 5 mm diameter critical-sized calvarial defects in Fish...

Chitosan is a cationic natural polysaccharide which is derived from the chitin of crustaceans, with crabs and shrimp-shell wastes as its principal source. Its properties includes extent of deacetylation and the average molecular weight of polymer as well as low toxicity and good bioavailability make it a novel excipient in pharmaceutical formulation as a relatively new development. Together wit...

Chitosan-one of the natural multifunctional polymers-due to its unique and versatile biological properties is regarded as a useful compound in medical and pharmaceutical technology. Recently, considerable research effort has been made in order to develop safe and efficient chitosan products. However, the problem of poor stability of chitosan-based systems restricts its practical applicability; ...

Blend membranes of chitosan and poly (ethylene oxide) with different molecular weights of 100,000 and 600,000 were prepared by the solution cast technique. The Chitosan-PEO blend membranes were produced to study their water adsorptions capacity and characteristics of the haemodialysis membrane application. An increase in the water adsorption capacity of chitosan-PEO blend membranes compared to ...

Chitosan, which is derived from a deacetylation reaction of chitin, has attractive antimicrobial activity. However, chitosan applications as a biocide are only effective in acidic medium due to its low solubility in neutral and basic conditions. Also, the positive charges carried by the protonated amine groups of chitosan (in acidic conditions) that are the driving force for its solubilization ...

The potential of chitin and its derivatives mainly chitosan extends to various existing and proposed applications in an unusually large number of fields. In the present study, the prospect for using the exoskeleton of cephalopods as a raw material for chitosan manufacture was tried out. This includes the extraction of chitin from the cuttlebone (by deproteinization and demineralization) and chi...