نتایج جستجو برای: Chronic constriction injury

تعداد نتایج: 786566  

Journal: :iranian journal of pharmaceutical research 0
alireza abed department of pharmacology and toxicology, school of pharmacy and pharmaceutical sciences, isfahan university of medical sciences, isfahan, iran valiollah hajhashemi department of pharmacology and toxicology and pharmaceutical research center, school of pharmacy and pharmaceutical sciences, isfahan university of medical sciences, isfahan, iran hamid reza banafshe department of addiction studies, school of medicine, kashan university of medical sciences, kashan. iran. mohsen minaiyan 1department of pharmacology and toxicology and pharmaceutical research center, school of pharmacy and pharmaceutical sciences, isfahan university of medical sciences, isfahan, iran azam mesdaghinia physiology research center, kashan university of medical sciences, kashan. iran.

primarily opioidergic and adenosine mechanisms are considered to be involved in the antinociceptive effects of antidepressants. this study was designed to determine the efficacy of acute venlafaxine administration in alleviating symptoms of neuropathic pain and the role of endogenous adenosine and opioid systems in this effect of venlafaxine. we have evaluated the effect of caffeine, a non-sele...

Journal: :thrita 0
atousa janzade physiology research center, faculty of medicine, iran university of medical sciences, tehran, ir iran; laboratory of basic sciences, department of basic sciences, faculty of allied medicine, iran university of medical sciences, tehran, ir iran seyed behnamedin jameie laboratory of basic sciences, department of basic sciences, faculty of allied medicine, iran university of medical sciences, tehran, ir iran; department of anatomy, faculty of medicine, iran university of medical sciences, tehran, ir iran; cellular and molecular research center, iran university of medical sciences, tehran, ir iran shahla choobchian department of management and agricultural development, faculty of agricultural economics and development, iran university, tehran, ir iran farinaz nasirinezhad physiology research center, faculty of medicine, iran university of medical sciences, tehran, ir iran; department of physiology, faculty of medicine, iran university of medical sciences, tehran, ir iran; physiology research center, faculty of medicine, iran university of medical sciences, tehran, ir iran. tel: +98-9121969564, fax: +98-2122748828

conclusions coq10 abolished neuropathic pain in cci rats. prevention of cell loss might be attributed to the analgesic effect of coq10. hence, it might be used as a therapeutic intervention for neuropathic pain. background oxidative stress contributes to neuropathic pain. coenzyme q10 (coq10) is used for the treatment of neurodegenerative diseases. however, there is no report regarding the ther...

ژورنال: کومش 2021

Introduction: There are various animal models to investigate neuropathic pain which the most usual one is chronic constriction injury method. The aim of the present study was the evaluation of neuropathic pain following chronic spiral suturing around the sciatic nerve without ligation as a new model. Materials and Methods: Thirty Wistar male rats, weighting 180-220 gram randomly were divided in...

Journal: :مجله علوم اعصاب شفای خاتم 0
mahboobeh ghasemzadeh rahbardar department of physiology, school of medical sciences, tarbiat modares university, tehran, iran bahareh amin cellular and molecular research center, department of physiology and pharmacology, faculty of medicine, sabzevar university of medical sciences, sabzevar, iran hossein hosseinzadeh pharmaceutical research center, department of pharmacodynamics and toxicology, school of pharmacy, mashhad university of medical sciences, mashhad, iran

introduction: rosemary, rosmarinus (r.) officinalis l. is a well-known plant with several useful properties such as analgesic, anti-inflammatory and anti-neurodegenerative. it has been used in folk medicine to alleviate rheumatic pain, stomachache and dysmenorrhea. rosemary has several constituents such as rosmarinic acid which can be responsible for therapeutic properties been noted with rosem...

Journal: :medical journal of islamic republic of iran 0
seyed behnamedin jameie department of medical basic sciences, faculty of allied medicine, iran university of medical sciences, tehran, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (iran university of medical sciences) masoumeh masoumipoor department of nuclear engineering, sciences and researches branch, islamic azad university, tehran, iran.سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (islamic azad university science and research branch) atousa janzadeh department of medical basic sciences, faculty of allied medicine, research center of physiology& department of physiology, faculty of medicine, iran university of medical sciences, tehran, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (iran university of medical sciences)سازمان های دیگر: research center of physiology& farinaz nasirinezhad research center of physiology& department of physiology, faculty of medicine, iran university of medical sciences, tehran, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (iran university of medical sciences) mahdieh kerdari department of medical basic sciences, faculty of allied medicine, iran university of medical sciences, tehran, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (iran university of medical sciences) maryam soleimani department of anatomy, faculty of medicine, iran university of medical sciences, tehran, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (iran university of medical sciences)

background: neuropathic pain (np) is one of the most suffering medical conditions that often fail to respond to certain pain therapy. although its exact etiology is still unknown the role of reactive oxygen species (ros) and oxidative stress were explored by many researchers. neuropathies either central or peripheral lead to painful condition as well as social and economic isolation, thus vario...

مناهجی, هما , نصیری‌نژاد, فریناز,

It has been reported that chromaffin cells secrete some neuroactive substances particularly opioid peptides and catecholamines which reduce pain. Adrenal medullary implant, have been used in other injury models to provide an endogenous source of catecholamines. The goal of the present study was to determine whether adrenal medullary implants in the spinal space could repair sensory and ...

Journal: :Folia Neuropathologica 2023

AMA Lu Z, Zhang Y, Li Y. LncRNA FTX ameliorates neuropathic pain by targeting miR-320a in a rat model of chronic constriction injury. Folia Neuropathologica. 2023. doi:10.5114/fn.2023.126846. APA Lu, Z., Zhang, Y., & Li, (2023). https://doi.org/10.5114/fn.2023.126846 Chicago Zhisheng, Yijue and Yunze Li. "LncRNA injury". Harvard MLA Zhisheng et al. injury." Neuropathologica, Vancouver

Journal: :Physiological research 2016
K Salte G Lea M Franek S Vaculin

Chronic constriction injury to the sciatic nerve was used as an animal model of neuropathic pain. Instead of frequently used reflex-based tests we used an operant thermal place preference test to evaluate signs of neuropathic pain and the effect of baclofen administration in rats with neuropathy. Chronic constriction injury was induced by four loose ligations of the sciatic nerve. Thermal place...

Ehsan Ramezanian Nick, Farinaz Nasirinezhad, Mahsa Sadeghi, Mohammad Fereshtenezhad,

Introduction: As sex differences have been observed repeatedly in chronic pain, it is likely that the gonadal hormones are responsible for these differences. To investigate the responsible mechanism for chronic pain different models have been created. This study is examining the effects of gonadal hormones on nociceptive responses of the rats in CCI (chronic constriction injury) and SNI (spread...

2018
Sascha RA Alles Esperanza Garcia Sridhar Balasubramanyan Karen Jones John R Tyson Twinkle Joy Terrance P Snutch Peter A Smith

Background Following peripheral nerve chronic constriction injury, the accumulation of the α2δ-1 auxiliary subunit of voltage-gated Ca2+ channels in primary afferent terminals contributes to the onset of neuropathic pain. Overexpression of α2δ-1 in Xenopus oocytes increases the opening properties of Cav1.2 L-type channels and allows Ca2+ influx at physiological membrane potentials. We therefore...

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