BACKGROUND We established a rat model of chronic mountain sickness using acetyl-L-cysteine. Then we studied the effects and mechanisms of acetyl-L-cysteine (Da) in rats with chronic mountain sickness using nuclear magnetic resonance (H1-NMR) metabolomics methods. MATERIAL AND METHODS Using NMR spectroscopy combined with pattern recognition and orthogonal partial least squares discriminant ana...

Arias-Stella, J., Kriiger, H., and Recavarren, S. (1973). Thorax, 28, 701-708. Pathology of chronic mountain sickness. Pathological data on chronic mountain sickness are scarce due to the fact that the disease is ameliorated or cured by descent to a low altitude. In this report we describe a case of chronic mountain sickness occurring in a woman of 48 years at Cerro de Pasco (4,300 m above sea ...

We survey old and new regularity theory for the Monge-Ampère equation, show its connection to optimal transportation, and describe the regularity properties of a general class of Monge-Ampère type equations arising in that context.

More than 140 million people worldwide live >2500 m above sea level. Of them, 80 million live in Asia, and 35 million live in the Andean mountains. This latter region has its major population density living above 3500 m. The primary objective of the present study is to review the physiology, pathology, pathogenesis, and clinical features of the heart and pulmonary circulation in healthy highlan...

Introduction Chronic mountain sickness (CMS) affects people who are native or long time residents of high altitude. It is characterized by an excessive erythrocytosis for the altitude of residence, severe hypoxemia and in many cases, particularly in severe CMS, high altitude pulmonary hypertension (HAPH). CMS usually begins insidiously in adult life associated probably to aging; the clinical pi...

I read with great interest the article by White et al,’ which appeared in the July 1991 issue ofChest. The authors raised several important points concerning the utility of chest radiographs in adults admitted for exacerbations of bronchial asthma, I feel, however, that several aspects oftheir study must be addressed. First ofall, the study is relatively small (n =58) and uncontrolled, and invo...

In this paper we consider the Monge-Ampère equation det(D2u) = f(x) in a convex domain Ω ⊂ IRn subject to the Dirichlet boundary condition u = φ on ∂Ω. We prove that if ∂Ω and φ are C3 smooth, then the solution u ∈ C2+α(Ω). We also give examples to show that if ∂Ω or φ is only C2,1 smooth, the solution may fail to be C2 smooth near the boundary.

We construct a special plurisubharmonic defining function for a smoothly bounded strictly pseudoconvex domain so that the determinant of the complex Hessian vanishes to high order on the boundary. This construction, coupled with regularity of solutions of complex Monge-Ampére equation and the reflection principle, enables us to give a new proof of the Fefferman mapping theorem.