Cancer chronotherapy aims at enhancing tolerability and efficacy of anticancer drugs through their delivery according to circadian clocks. However, mouse and patient data show that lifestyle, sex, genetics, drugs, and cancer can modify both host circadian clocks and metabolism pathways dynamics, and thus the optimal timing of drug administration. The mathematical modeling of chronopharmacology ...

Chronopharmacology is an area where the drug administration (dosing regimen) synchronized with biological rhythms so as to maximize therapeutic effect. It involves both the investigation of drug effects as a function of biologic timing and the investigation of drug effects upon rhythm characteristics. The major objective of this article is to inform biologists, clinicians, pharmaceutical scient...

Approximately one-third of patients with epilepsy continue to have seizures despite antiepileptic therapy. Many seizures occur in diurnal, sleep/wake, circadian, or even monthly patterns. The relationship between biomarkers and state changes is still being investigated, but early results suggest that some of these patterns may be related to endogenous circadian patterns whereas others may be re...