Cigarette smoke contains around 4000 chemical substances including free radicals and carcinogens, which are xenobiotic agents in the body, affecting the reproductive system. Purple sweet potatoes contain the color pigment anthocyanin. The purple color pigment (anthocyanin) in purple sweet potatoes is a beneficial antioxidant because it can react with free radicals that can cause damage in the b...

Effects of tobacco smoke on hematologic derangements have received little attention. This study employed a mouse model of cigarette smoke exposure to explore the effects on bone marrow niche function. While lung cancer is the most widely studied consequence of tobacco smoke exposure, other malignancies, including leukemia, are associated with tobacco smoke exposure. Animals received cigarette s...

previous studies demonstrated that cse induces oxidative stress and its consequences on isolated mitochondria obtained from lung, heart and brain which may provide insight into the role of cse in human health and disease. the present study was carried out to further characterize and compare toxic effect of cse extract on isolated mitochondria obtained from either a directly contacting tissue (i...

RATIONALE Lung injury after cigarette smoking is related to particle retention. Iron accumulates with the deposition of these particles. OBJECTIVES We tested the postulate that (1) injury after smoking correlates with exposure to the particulate fraction of cigarette smoke, (2) these particles alter iron homeostasis, triggering metal accumulation, and (3) this alteration in iron homeostasis a...

TO THE EDITOR: We read with interest the article by Aravamudan and colleagues (1) on cigarette smoke-induced mitochondrial fragmentation and dysfunction in human airway smooth muscle. As explained in a recent Perspectives (4), mitochondria are at the center of a reactive oxygen species-dependent pathway regulating cellular cytotoxic responses. The study by Aravamudan et al. demonstrates that ci...

It has been shown, that smoking results in a lower yield of surfactant associated phospholipids in bronchoalveolar lavage (BAL). Indirect evidence suggests impaired secretion. In the present study, we investigated the influence of cigarette smoke on surfactant secretion in cultured rat alveolar type II cells. Smoke exposure was achieved by bubbling the smoke of four cigarettes through Dulbecco'...

Background: The present systematic review and meta-analysis is designed in order to assess the association between passive and active smoking and lipid profile of children and adolescents. Materials and Methods:  An extensive search was done in databases of Medline, EMBASE, Web of Science, Scopus and CINAHL until October 2017. Two independent researchers screened articles and in the next step, ...

The deleterious role of cigarette smoke has long been documented in various human diseases including periodontal complications. In this report, we examined this adverse effect of cigarette smoke on human gingival fibroblasts (HGFs) which are critical not only in maintaining gingival tissue architecture but also in mediating immune responses. As well documented in other cell types, we also obser...

Background & Aims: Exposure to cigarette smoke affects the health of mothers and infants. The aim of this study was to examine the effects of second-hand smoke exposure on breast milk and infant urinary cotinine during breastfeeding. Methods: This cohort study was conducted on 45 breastfeeding mothers and infants exposed to second-hand cigarette smoke (exposed group), and 40 breastfeeding mothe...

PURPOSE Cigarette smoke is the major risk factor associated with the development of chronic obstructive pulmonary disease (COPD). Recent studies propose a link between endoplasmic reticulum (ER) stress and emphysema, demonstrated by increased ER stress markers under smoking conditions. Here, we investigate whether cigarette smoke-induced ER stress is cell specific and correlates with acute and ...