نتایج جستجو برای: Clofazimine

تعداد نتایج: 519  

Journal: :The Journal of antimicrobial chemotherapy 2015
Shuo Zhang Jiazhen Chen Peng Cui Wanliang Shi Wenhong Zhang Ying Zhang

OBJECTIVES Although clofazimine has been traditionally used to treat leprosy, there is recent interest in using clofazimine for the treatment of MDR-TB and drug-susceptible TB. However, the mechanisms of resistance to clofazimine are poorly understood. Here, we investigated the molecular basis of clofazimine resistance using resistant mutants isolated in vitro. METHODS We isolated 96 mutants ...

Journal: :Antimicrobial agents and chemotherapy 2016
Rosemary V Swanson Nicole C Ammerman Bongani Ngcobo John Adamson Chivonne Moodley Afton Dorasamy Sashen Moodley Zinhle Mgaga Linda A Bester Sanil D Singh Deepak V Almeida Jacques H Grosset

Experimental and clinical studies have indicated that the antileprosy drug clofazimine may contribute treatment-shortening activity when included in tuberculosis treatment regimens. Clofazimine accumulates to high levels in tissues, has a long half-life, and remains in the body for months after administration is stopped. We hypothesized that in tuberculosis treatment, accumulated clofazimine ma...

Journal: :Antimicrobial agents and chemotherapy 2011
Yasuo Fukutomi Yumi Maeda Masahiko Makino

Clofazimine is a riminophenazine compound which has been used for the treatment of leprosy since the 1960s. Although the drug is effective in the management of leprosy reactions because of its anti-inflammatory activity, the mechanism leading to the cessation of inflammation is not well understood. In the present study, it was shown that clofazimine exhibits apoptosis-inducing activity in macro...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2015
Sandeep Tyagi Nicole C Ammerman Si-Yang Li John Adamson Paul J Converse Rosemary V Swanson Deepak V Almeida Jacques H Grosset

A key drug for the treatment of leprosy, clofazimine has recently been associated with highly effective and significantly shortened regimens for the treatment of multidrug-resistant tuberculosis (TB). Consequently, we hypothesized that clofazimine may also shorten the duration of treatment for drug-susceptible TB. We conducted a controlled trial in the mouse model of TB chemotherapy comparing t...

Journal: :The European respiratory journal 2017
Margareth Dalcolmo Regina Gayoso Giovanni Sotgiu Lia D'Ambrosio Jorge L Rocha Liamar Borga Fatima Fandinho Jose U Braga Vera M N Galesi Draurio Barreira Denise A Sanchez Fernanda Dockhorn Rosella Centis Jose A Caminero Giovanni B Migliori

Although clofazimine is used to treat multidrug-resistant tuberculosis (MDR-TB), there is scant information on its effectiveness and safety. The aim of this retrospective, observational study was to evaluate these factors as well as the tolerability of clofazimine in populations in Brazil, where it was administered at a daily dose of 100 mg·day-1 (body weight ≥45 kg) as part of a standardised M...

Journal: :The Journal of antimicrobial chemotherapy 2004
Brunello Oliva Alexander John O'Neill Keith Miller William Stubbings Ian Chopra

OBJECTIVES Infections caused by Staphylococcus aureus might be treated with agents whose primary indications are for other infections. Clofazimine, an established anti-mycobacterial drug, could be such a candidate. However, the anti-staphylococcal properties of clofazimine have not been fully described and its mode of action, possibly involving inhibition of both RNA polymerase and a membrane-l...

Journal: :International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association 1976
N E Morrison G M Marley

1. The antileprosy drug, clofazimine, formed stable complexes with DNA and transfer RNA. A quantitative study was made of the spectral red shifts that occurred when clofazimine interacted with DNA. The red shift appeared specific for clofazimine binding to nucleic acid polymers. 2. The degree of clofazimine interaction with DNA was related to the G+C content of the DNA strand. As compared to th...

2017
Yingyue Zhang Jie Feng Simon A McManus Hoang D Lu Kurt D Ristroph Eugene J Cho Ellen L Dobrijevic Hak-Kim Chan Robert K Prud'homme

Clofazimine, a lipophilic (log P = 7.66) riminophenazine antibiotic approved by the US Food and Drug Administration (FDA) with a good safety record, was recently identified as a lead hit for cryptosporidiosis through a high-throughput phenotypic screen. Cryptosporidiosis requires fast-acting treatment as it leads to severe symptoms which, if untreated, result in morbidity for infants and small ...

Journal: :Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2015
Arbace Officioso Kousi Alzoubi Caterina Manna Florian Lang

BACKGROUND/AIMS The antimycobacterial riminophenazine clofazimine has previously been shown to up-regulate cellular phospholipase A2 and to induce apoptosis. In erythrocytes phospholipase A2 stimulates eryptosis, the suicidal erythrocyte death characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine translocation to the erythrocyte surface. Phospholipase A2 is in par...

Journal: :Leprosy review 1997
K Venkatesan A Mathur A Girdhar B K Girdhar

Clofazimine is an important and effective constituent of multi drug therapy for leprosy. A study has been conducted to determine the distribution of clofazimine in maternal milk so that the safety of breast-feeding during maternal ingestion of the drug can be ascertained. Eight female leprosy patients (LL/BL) on clofazimine, 50 mg daily or 100 mg on alternate days for 1-18 months, (mean 5.0 +/-...

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