Corms and the above ground parts of the yellow meadow saffron (Colchicum luteum Baker) have been proposed for the isolation of colchicine and colchamine in our country. Corms are collected and stored in large quantities for the extraction which result in rapid depletion of the raw material sources. In order to investigate the effects of chitosan on germination and growth of corms of Colchicum l...

An in-house strategy to dereplicate colchicinoid alkaloids was recently developed by our team. It aimed at quickly identifying Colchicum constituents using LC-MS (liquid chromatography-mass spectroscopy) and LC-UV/Vis PDA (liquid chromatography-ultraviolet/ visible photodiode array) techniques. In this project, our goal was to validate the developed method through analysing the alkaloid-rich fr...

INTRODUCTION Colchicum autumnale, commonly known as the autumn crocus, contains alkaloid colchicine with antimitotic properties. CASE REPORT A 76-year-old man with a history of alcoholic liver disease and renal insufficiency, who mistakenly ingested Colchicum autumnale instead of wild garlic (Aliium ursinum), presented with nausea, vomiting and diarrhea 12 hours after ingestion. On admission ...

As a part of a project designed to investigate Colchicum species in Jordan, the chemical constituents of Colchicum crocifolium Boiss. (Colchicaceae) were investigated using LC-MS and LC-UV/Vis PDA. A decision tree for working with colchicinods has been developed by incorporating data from LC-UV/PDA and LC-MS. This dereplication strategy draws upon the UV/PDA spectra to classify compounds into o...

Representatives of the genus Epimedium L. (family Berberidaceae) are herbaceous spring-flowering perennials with medicinal and decorative significance. The collection VILAR Botanical Garden contains three species Russian Federation flora - E. colchicum (Boiss.) Trautv., koreanum Nakai, macrosepalum Stearn hybrid taxa widely used as ornamental plants х rubrum Morren, versicolor warleyense Stearn...

PURPOSE Cancer is a long process that leads the organism to death and is associated with the normal cells acquiring the ability to divide permanently. Nowadays, the use of natural products in cancer therapy has a great importance. In addition, working with plants that are endemic to Turkey and determining the biological activities of these plant extracts, is extremely important due to the poten...

As part of our continuing investigation of Jordanian Colchicum species, the biologically active components of Colchicum brachyphyllum were pursued. Using bioactivity-directed fractionation, nine colchicinoids were isolated and characterized. One of these has a novel ring system, to which we have ascribed the trivial name (+)-demecolcinone (9), and it represents the first naturally occurring dex...