Background and objectives: The genus Colchicum belongs to the family Colchicaceae, which comprises of 19 genera, and 225 species worldwide. They have been recognized for more than 2000 years for their noticeable biological properties. The Colchicum species are well known for presence of tropolonic alkaloids, mainly colchicine. Colchicine, is still the drug of ...

Background: Colchicum is a genus of the Colchicaceae family with various isolated compounds, especially tropolone alkaloids and flavonoids, which are used for osteoarthritis, gout, cancer, inflammatory diseases, jaundice, sexual impotence in different societies. Objectives: The current study aimed to evaluate phytochemical physicochemical properties anti-inflammatory activities three species. M...

Arisaema speciosum is a wild lily of family Araceae. This paper reports anti-inflammatory properties of the ethanolic extract of the corm of Arisaema speciosum .The ethanolic extract of corm of Arisaema speciosum showed in vitro cytotoxic effect against Ehrlich ascitic cells. When the extract was injected in tumour bearing mice, tumour disappeared in 40% animals. Injection of ethanolic extract ...

An in-house strategy to dereplicate colchicinoid alkaloids was recently developed by our team. It aimed at quickly identifying Colchicum constituents using LC-MS (liquid chromatography-mass spectroscopy) and LC-UV/Vis PDA (liquid chromatography-ultraviolet/ visible photodiode array) techniques. In this project, our goal was to validate the developed method through analysing the alkaloid-rich fr...

Several species within the genus Theobroma have particularly high economic value, including T. cacao and T. grandiflorum. Other species in this genus, such as T. speciosum and T. subincanum, have potential value for use in the conservation of genetic diversity in breeding programs. These latter species could also be domesticated or improved to produce commercial products. Using 13 simple sequen...

Drosophila speciosa sp. nov. from: Belém, Pará, Brazil, is described and morphologically compared to a closely related species, D. aguape Val & Marques, 1996. Adult specimens of D. speciosa sp. nov. were collected while visiting T. speciosum Willd. ex Spreng. flowers in EMBRAPA’s Theobroma Linnaeus germoplasm collections (113 individuals) in Belém and in Caxiuanã Scientific Station, in Melgaço,...

BACKGROUND Six plants from Thailand were evaluated for their cytotoxicity and apoptosis induction in human hepatocarcinoma (HepG2) as compared to normal African green monkey kidney epithelial cell lines. METHODS Ethanol-water crude extracts of the six plants were tested with neutral red assay for their cytotoxicity after 24 hours of exposure to the cells. Apoptotic induction was tested in the...

As a part of a project designed to investigate Colchicum species in Jordan, the chemical constituents of Colchicum crocifolium Boiss. (Colchicaceae) were investigated using LC-MS and LC-UV/Vis PDA. A decision tree for working with colchicinods has been developed by incorporating data from LC-UV/PDA and LC-MS. This dereplication strategy draws upon the UV/PDA spectra to classify compounds into o...

PURPOSE Cancer is a long process that leads the organism to death and is associated with the normal cells acquiring the ability to divide permanently. Nowadays, the use of natural products in cancer therapy has a great importance. In addition, working with plants that are endemic to Turkey and determining the biological activities of these plant extracts, is extremely important due to the poten...