نتایج جستجو برای: Com1

تعداد نتایج: 76  

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2000
A H Ree M M Pacheco M Tvermyr O Fodstad M M Brentani

Tumor cells and their surrounding microenvironment produce a variety of growth factors and proteolytic enzymes to promote tumor growth and metastasis. We have recently identified a novel factor, termed com1, which is up-regulated in human breast carcinoma cells upon formation of experimental metastatic tumors and assumed to act as a growth-promoting factor in breast cancer. In attempts to explo...

Journal: :Molecular pharmacology 1999
K Neplechová J Kaspárková O Vrána O Nováková A Habtemariam B Watchman P J Sadler V Brabec

Mechanistic studies are presented of a novel class of aminophosphine platinum(II) complexes as potential anticancer agents. These new agents, which have demonstrated activity against murine and human tumor cells including those resistant to cisplatin are cis-[PtCl2(Me2N(CH2)3PPh2-P)2] (Com1) and cis-[PtCl(C6H11NH(CH2)2PPh2-N,P)(C6H11NH(CH2) 2PPh2-P)] (Com2). We studied modifications of natural ...

2014
Hua-Wei Chen Zhiwen Zhang Erin Glennon Wei-Mei Ching

Currently, the accepted method for Q fever serodiagnosis is indirect immunofluorescent antibody assay (IFA) using the whole cell antigen. In this study, we prepared the recombinant antigen of the 27-kDa outer membrane protein (Com1) which has been shown to be recognized by Q fever patient sera. The performance of recombinant Com1 was evaluated in ELISA by IFA confirmed serum samples. Due to the...

Journal: :Journal of bacteriology 2012
Stephanie L Bridger W Andrew Lancaster Farris L Poole Gerrit J Schut Michael W W Adams

The model archaeon Pyrococcus furiosus grows optimally near 100°C on carbohydrates and peptides. Its genome sequence (NCBI) was determined 12 years ago. A genetically tractable strain, COM1, was very recently reported, and here we describe its genome sequence. Of 1,909,827 bp in size, it is 1,571 bp longer (0.1%) than the reference NCBI sequence. The COM1 genome contains numerous chromosomal re...

Journal: :Journal of clinical microbiology 1998
G Q Zhang S V Nguyen H To M Ogawa A Hotta T Yamaguchi H J Kim H Fukushi K Hirai

A nested PCR method was developed for the detection of Coxiella burnetii in human serum samples. Two pairs of oligonucleotide primers were designed to amplify a 438-bp fragment of the com1 gene encoding a 27-kDa outer membrane protein of C. burnetii. The primers amplified the predicted fragments of 21 various strains of C. burnetii but did not react with DNA samples from other microorganisms. T...

Journal: :The EMBO journal 2007
Clemens Uanschou Tanja Siwiec Andrea Pedrosa-Harand Claudia Kerzendorfer Eugenio Sanchez-Moran Maria Novatchkova Svetlana Akimcheva Alexander Woglar Franz Klein Peter Schlögelhofer

Obligatory homologous recombination (HR) is required for chiasma formation and chromosome segregation in meiosis I. Meiotic HR is initiated by DNA double-strand breaks (DSBs), generated by Spo11, a homologue of the archaebacterial topoisomerase subunit Top6A. In Saccharomyces cerevisiae, Rad50, Mre11 and Com1/Sae2 are essential to process an intermediate of the cleavage reaction consisting of S...

Coxiella burnetiiis an obligate and gram-negative bacteria causing query fever (Q fever) disease, despite the importance of Q fever, there is no universal vaccine against this disease. Therefore, application of the recombinant subunit vaccines which use Com1 and OmpH as immunogenic proteins can be useful in this regard. To perform the current project, Com1 an...

Journal: :Infection and immunity 1993
L R Hendrix L P Mallavia J E Samuel

The gene for an approximately 27-kDa outer membrane-associated, immunoreactive protein was cloned from the rickettsial pathogen Coxiella burnetii. The gene, designated com1 for Coxiella outer membrane protein 1, was expressed in Escherichia coli, presumably by its own promoter. The complete nucleotide sequence of the gene was determined. The deduced amino acid sequence of 252 residues includes ...

2004
Loree Heller M. Lee Lucas

Loree Heller and M. Lee Lucas Center for Molecular Delivery, University of South Florida, Tampa, FL 33612, Department of Medical Microbiology, University of South Florida, Tampa, FL 33612 __________________________________________________________________________________ * Correspondence : Loree Heller, University of South Florida, Center for Molecular Delivery, MDC16, 12901 Bruce B. Downs Blvd....

Journal: :Agronomy 2022

In hyper-arid and arid zones, management of crop water requirements is considered a vital component for sustaining production. The efficiency the irrigation method application many kinds organic matter are practices that should be followed in Egypt to maximize use water. Two field experiments were conducted during two successive winter seasons 2020/2021 2021/2022 study effect drip systems sever...

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