background: the pathogenesis of gestational trophoblastic disease (gtd) is not clearly known. objective: in this study, immunoexpression of proteins bcl-2 and beclin-1 in trophoblastic lesions and normal trophoblastic tissue was conducted to study the mechanism of apoptotic and autophagic cell death that is expected to complete the study of gtd pathogenesis. materials and methods: bcl-2 and bec...

BACKGROUND The pathogenesis of Gestational Trophoblastic Disease (GTD) is not clearly known. OBJECTIVE In this study, immunoexpression of proteins Bcl-2 and Beclin-1 in trophoblastic lesions and normal trophoblastic tissue was conducted to study the mechanism of apoptotic and autophagic cell death that is expected to complete the study of GTD pathogenesis. MATERIALS AND METHODS Bcl-2 and Be...

Background Gestational trophoblastic disease is a group of benign and malignant entities, where the hydatidiform mole is the most common, and can be divided into complete hydatidiform mole and partial hydatidiform mole. However, the histological criteria are still questionable and also, histologic evaluation alone is prone to great interobserver variability. In this way, inmunohistochemical ana...

Gestational trophoblastic disease (GTD) represents a spectrum of lesions characterised by an abnormal proliferation of trophoblast, including complete hydatidiform mole, partial hydatidiform mole, invasive hydatidiform mole, choriocarcinoma, placental site trophoblastic tumour, epithelioid trophoblastic tumour, placental site nodule and plaque, and exaggerated placental site reaction. Complete ...

Tubal pregnancies are common but presence of hydatidiform mole in tube is a rare entity. A woman of 53years presented with acute abdomen, preoperative pregnancy test was positive and ultrasonography suspected the case as hydatidiform mole in right tube. The patient was treated with total abdominal hysterectomy with bilateral salpingo-oophorectomy as her family was completed. Subsequent histopat...

initial management, incidence and review of hydatidiform mole, chorioadenoma and destruens and chorio carcinoma in mirza kochek khan hospital department of ob.gyn and gynecology oncology of women's hospital tehran-iran school of medicin from september 1985 to march 1990, 209 patients received primary management for hydatidiform mole at oncology department of mirza kochek khan hospital medi...

normal 0 false false false microsoftinternetexplorer4 background : despite well-described histopathologic criteria, the distinction of spontaneous abortion from hydatidiform mole and complete hydatidiform mole from partial hydatidiform mole remains a problem because of interobserver and intraobserver variability. the aim of this study was to evaluate the value of two immunohistochemical markers...

Recurrent hydatidiform mole is defined as episodes of two molar pregnancies in a female. Often, complete moles onlyderive androgenic nuclear genome. We described two cases with repeated molar pregnancies attempted to preventfuture episodes by performing intracytoplasmic sperm injection (ICSI) and preimplantation genetic diagnosis (PGD)to assess genetic disorders. The first pat...