manufacturing new hepatitis b virus vaccines, specifically by the use of nanoparticles, is of high global interest. in this paper, a new biocompatible and biodegradable structure of nano-sized hepatitis b virus’ surface antigen (hbsag) was generated by conjugation with dendrimers, a low cost biodegradable and biocompatible polymer. the physicochemical properties of the conjugate were characteri...

conclusions vaccine based on the conjugation of p. aeruginosa pao-1 lps with dt increased anti-lps antibodies and had a significant potential to protect against pseudomonas infections. background treatment of pseudomonas aeruginosa pao-1 infections through immunological means has been proved to be efficient and protective. objectives the purpose of this study was to produce a conjugate vaccine ...

S.typhimurium is a gram negative bacterium causing serious enteric or extraintestinal infections in human, cattle and birds. These kinds of infections may lead to some permanent or nonpermanent complications like endophthalmitis, Guillain-Barre syndrome and osteomyelitis . Multi-resistant strains of S.typhimurium have been reported from several countries, and these infections are a major public...

Children 12-18 months old were randomized to receive one dose of a conjugate heptavalent pneumococcal vaccine, two doses of the same vaccine, or one dose of a 23-valent native polysaccharide vaccine. Before immunization, pneumococci included in the conjugate vaccine were isolated from 24% of the children, and an antibiotic-resistant pneumococcus was isolated from 22% of the children. The vaccin...

children under 2 years of age suffer from some of the highest rates of invasive pneumococcal disease (ipd) in the world. (turkey) rates of ipd had a decline after statewide introduction of the 7-valent pneumococcal conjugate vaccine (pcv7) in 2008. introduction of pcv7, pcv10 and pcv13 vaccines resulted in elimination of ipd caused by vaccine serotypes, but was followed by increasing rates of i...

BACKGROUND We recently showed that vaccination with a 7-valent pneumococcal conjugate vaccine (PCV7) followed by a 23-valent pneumococcal polysaccharide vaccine (PPSV23) failed to prevent new episodes of acute otitis media (AOM) in previously unvaccinated toddlers and children with a history of recurrent AOM. We describe in detail the impact of pneumococcal vaccinations on nasopharyngeal carria...

haemophilus influenzae, a major cause of meningitis in young children leading to death and other neurological sequelae. the disease leaves 15 to 35% of the survivors with permanent disabilities, such as, mental retardation or deafness. despite the availability of new and more powerful antibiotics children with hib meningitis still suffer from high mortality or morbidity. the emergence of multir...

Two hundred twenty-one Gambian children vaccinated previously with one, two, or three doses of a meningococcal conjugate vaccine or two doses of polysaccharide vaccine before the age of 6 months were revaccinated at the age of 18-24 months with either meningococcal polysaccharide, conjugate, or inactivated polio vaccines. Children who had previously received one, two, or three doses of conjugat...

Children with frequent recurrent episodes of otitis media may have a deficient IgG2 antibody response to polysaccharide antigens. Five otitis-prone children were vaccinated with heptavalent pneumococcal conjugate vaccine. While all had an IgG1 antibody response to all pneumococcal serotypes included in the conjugate vaccine, the IgG2 response, especially to serotypes 6B, 9V, 19F, and 23F, was p...