severe acute respiratory syndrome (sars) is a fetal communicable respiratory disease, known as atypical pneumonia. this disease first appeared in china on november 2002 and spread very fast in various parts of the world especially in asia. number of reported cases of sars from november 2002 to may 2003 were about 8046 of which 6825 patients died. sars is caused by coronavirus, and symptoms of d...

Abbreviations: BtCoV-HKU4: Bat Coronavirus HKU4; BtCoVHKU5: Bat Coronavirus HKU5; DPP4: DiPeptidyl Peptidase 4; ECDC: European Centre for Disease Prevention and Control; HACE2: Human Angiotenssion Converting Enzyme 2; HCoV-229E: Human Coronavirus 229E; HCoV-HKU1: Human Coronavirus HKU1; HCoVNL63: Human coronavirus NL63; HCoV-OC43: Human Coronavirus OC43; HCP: HealthCare Personnel; HCW: Health C...

two male dogs at the age of 3 and 5 months of doberman pinscher and german shepherd breeds were referred to the veterinary hospital of ahvaz university with clinical signs of depression, vomiting, haemorrhagic diarrhoea, profound dehydration, fever and anorexia. the affected dogs had not the history of vaccination. concurrent infection of canine parvovirus and coronavirus was detected in dogs b...

a 1:1 matched case-control study of calves under 1 month of age was carried out by weekly visits to 7 dairy farms in mashhad from may 2008 to october 2008. fecal samples were collected from a total of 112 calves with clinical signs of diarrhea and from 112 matched animals without clinical signs of diarrhea as assessed by a scoring system. the samples were investigated for the presence of rotavi...

Recently, we reported the discovery of three novel coronaviruses, bulbul coronavirus HKU11, thrush coronavirus HKU12, and munia coronavirus HKU13, which were identified as representatives of a novel genus, Deltacoronavirus, in the subfamily Coronavirinae. In this territory-wide molecular epidemiology study involving 3,137 mammals and 3,298 birds, we discovered seven additional novel deltacorona...

Background: Coronavirus spike protein N-terminal domains (NTDs) bind sugar or protein receptors. Results:We determined crystal structure of bovine coronavirus NTD and located its sugar-binding site using mutagenesis. Conclusion: Bovine coronavirus NTD shares structural folds and sugar-binding sites with human galectins and has subtle yet functionally important differences from protein-binding N...

Rhinoviruses and coronaviruses are recognized as the major causes of the common cold syndrome. The role of these viruses in more serious respiratory illnesses resulting in hospitalization is less well defined. During a winter when influenza A infection was prevalent, 100 elderly adults hospitalized because of cardiopulmonary illnesses were evaluated for rhinovirus and coronavirus infection. Pat...

Antisera prepared against each of three single and one pair of major structural proteins of the bovine coronavirus (Mebus strain) were used in immunoblotting studies to measure cross-reactivity with the structural proteins of the human coronavirus OC43 and the mouse hepatitis coronavirus A59. We conclude that the bovine coronavirus is comprised of four major structural proteins, gp190 (normally...

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acute respiratory syndrome. New Engl. J. Med. 348, 1953–1966 3 Drosten, C. et al. (2003) Identification of a novel coronavirus in patients with severe acute respiratory syndrome. New Engl. J. Med. 348, 1967–1976 4 Peiris, J.S.M. et al. (2003) Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet 361, 1319–1325 5 Ruan, Y.J. et al. (2003) Comparative full-length genome sequ...