lidocaine (lc) is a local anesthetic agent. the aim of this study was to prolong the anesthetic effect of this drug in the oral cavity in the treatment of oral mucositis. films of lc were prepared with three different molecular weights (mw) of chitosan in three different concentrations (1-3%) and were then cross-linked by solvent casting evaporation method with tripolyphosphate penta sodium sal...

in this study, modified starch was used as a fat replacer in the milk. the fat replacer was manufactured from modified starch such as pre-gelatinized and cross–linked starches. modified starches were manufactured by hydrochloric acid and citric acid treatments from potato and wheat and were added to skim milk at concentrations of 0.15%, 0.30% and 0.45%. viscosity, total solid, fat content, titr...

penicillin g acylase from e. coli ta1 was immobilized by cross-linked enzyme aggregates (clea), a new method for immobilization. this biocatalyst and commercial immobilized penicillin g acylase (pga-450) were used to study the effect of ph, temperature and substrate concentration on the synthesis of ampicillin from phenyl glycine methyl ester (pgme) and 6-aminopenicillanic acid (6-apa). compare...

objective(s) the immunoadjuvant potential of cross-linked dextran microspheres (cdm) as absorption enhancer and quillaja saponins (qs) as immunomodulator adjuvant was evaluated. materials and methods cdm loaded or tetanus-mixed toxoid (tt) or quillaja saponin (qs) were nasally administered to rabbits in dry powder form, three times in 2 weeks interval and serum igg and nasal lavage siga titers ...

intranasal vaccination is particularly a striking route for mucosal immunization, due to the ease of administration and the induction of both mucosal and humoral immunity. however, soluble antigens (ag) are not sufficiently taken up after the nasal administration and need to be co-administered with adjuvants, penetration enhancers or encapsulated in particles. so, in this study, tetanus toxoid ...

A novel sulfonated polybenzimidazole/organoclay (Cloisite-30B) (SPBI/clay) nanocomposite membranes was successfully synthesized based on aromatic diacide (1) and diaminobenzidine. Nanocomposite membranes were fabricated using 1, 4-bis (hydroxymethyl) benzene (BHMB) as cross-linker, and Cloisite-30B organoclay as the pseudo cross-linker. The cross-linked SPBI/clay nanocomposite membranes were pr...