The objective of this study is to develop crystallo-co-agglomeratesof metronidazole having improved physicochemical, compressibility andsolubility properties. process agglomeration employed the use ofdichloromethane (good solvent), ethanol (bridging liquid) and distilled water (poorsolvent). Micromeritic properties co-agglomerates werestudied in terms bulk density, tapped Carr's index, Hausner’...

Spherical crystallization of drugs is the process of obtaining larger particles by agglomeration during crystallization. The most common techniques used to obtain such particles are spherical agglomeration and quasi-emulsion solvent diffusion. Ammonia diffusion systems and crystallo-co-agglomeration are extensions of these techniques. By controlling process parameters during crystallization, su...