leukemia is a blood disease which is caused by the inhibition of differentiation and an increased proliferation rate. nature has been known as a rich source of medically useful substances. high diversity of bioactive molecules extracted from marine invertebrates, makes them ideal candidates for cancer researches. the study has been done to investigate cytotoxic effects of dichloromethane brittl...

background and objectives: iran owns a rich and prestigious heritage of medicinal herbs but the majority of these plants have not yet undergone chemical, pharmacological and toxicological studies. in the present study some species form northern parts of iran were evaluated for cytotoxicity. methods: sixteen medicinal plants were extracted with methanol and screened for their cytotoxic activitie...

the current study was assigned to evaluate the total phenol, total flavonoid content (tpc, tfc) and antioxidant properties of extracts from the aerial parts of scrophularia frigida (s. frigida). extracts were also tested by preliminary phytochemical screening as well as cytotoxic activity against artemia salina, mcf-7 (human breast carcinoma) and sw-480 (colon carcinoma) and l-929 (normal) cell...

background: in spermatogenesis, spermatogonial cells differentiate to the haploid gametes. it has been shown that spermatogenesis can be done at in vitro condition. in vitro spermatogenesis may provide an open window to treat male infertility. objective: the aim of this study was to evaluate the effects of a novel scaffold containing human serum albumin (hsa)/tri calcium phosphate nanoparticles...

dna intercalators belong to aromatic heterocyclic compounds interacting reversibly with dna. these compounds have been used extremely as cytotoxic agents against cancer. in this study, the synthesis and biological activity of some novel derivatives of cyclopenta [b] quinoline-1, 8-dione as new intercalating agent were investigated. twenty novel derivatives of cyclopenta [b] quinoline-1, 8-dione...

the present study was carried out to investigate cytotoxic activity of flower, leaf, stem and root extracts of five artemisia species against breast cancer cell line (mcf7) and human embryonic kidney normal cell line (hek293). the studied artemisia species were a. absinthium , a. vulgaris , a. incana , a. fragrans and a. spicigera . the cytotoxic activity was measured by mtt assay at different ...

objective: verotoxin is a member of shiga toxin family. this family contains ab protein toxins with an enzymatic (a) and a binding (b) compartment. cells that have receptor (gb3) are sensitive to cytotoxic effects of toxin. it has been shown that various tumor cells have gb3 receptor and are selectively sensitive to apoptotic effect of verotoxin. studies on tumor cell lines and laboratory anima...

the present study was designed to investigate the anti-melanogenic and cytotoxic activities of methanol extract of phlomis kurdica. the antioxidant and anti-tyrosinase activity of meoh extract from p. kurdica (mpk) were examined by dpph radical scavenging and mushroom tyrosinase activity assays (in vitro), respectively. furthermore, the effect of mpk on the melanin content, cellular tyrosinase ...

objective: a number of studies have demonstrated the potential antitumor effects of saffron and its constituents on different malignant cells in vitro. it has been reported that a novel glycoconjugate isolated from corms and callus of saffron possesses cytotoxic activity against different tumor cellswith nitric oxide (no) production. these data suggest that the cytotoxic effect of saffron extra...