In 2005, a human adenovirus strain (formerly known as HAdV-D22/H8 but renamed here HAdV-D53) was isolated from an outbreak of epidemic keratoconjunctititis (EKC), a disease that is usually caused by HAdV-D8, -D19, or -D37, not HAdV-D22. To date, a complete change of tropism compared to the prototype has never been observed, although apparent recombinant strains of other viruses from species Hum...

The feasibility of fabricating a single component with copper and stainless steel multi-material structure can broaden its functional properties offer significant value in engineering design. In an effort to join 304L (SS304L) using the laser metal deposition technique, pure was deposited on SS304L both directly via interlayers nickel-based alloy Deloro 22 (D22). microstructure, elemental distr...

BACKGROUND In this open-label phase I study, the maximum-tolerated dose of cetuximab with concurrent chemoradiotherapy (C-CRT) in stage III non-small-cell lung cancer together with individualized, isotoxic accelerated radiotherapy (RT) was investigated. METHODS Patients with stage III non-small-cell lung cancer, World Health Organization performance status 0-1, forced expiratory volume in 1 s...

In this paper the failure of Hardy’s nonlocality proof for the class of maximally entangled states is considered. A detailed analysis shows that the incompatibility of the Hardy equations for this class of states physically originates from the fact that the existence of quantum perfect correlations for the three pairs of two-valued observables (D11,D21), (D11,D22), and (D12,D21) [in the sense o...

PURPOSE Epidemic keratoconjunctivitis (EKC) is a severe ocular infection caused by a few types (8, 19a [relabeled as 64 recently], 37, 53, and 54) of human adenoviruses (HAdVs). HAdVs are known for their strong host species specificity that limits studying HAdV virulence and pathophysiology in animal models. METHODS A HAdV infection model of primary porcine corneal epithelial cells (PPCE) and...

2 Description of SANS Instruments . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 707 2.1 The Steady-State Instrument D22 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 708 2.2 The Time-of-Flight Instrument LOQ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ....

2 Description of SANS Instruments . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 707 2.1 The Steady-State Instrument D22 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 708 2.2 The Time-of-Flight Instrument LOQ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ....

Multiphoton microscopy has emerged in the past decade as a promising tool for noninvasive skin imaging. Our aim was to evaluate the potential of multiphoton microscopy to detect topical corticosteroids side effects within the epidermis and to provide new insights into their dynamics. Healthy volunteers were topically treated with clobetasol propionate on a small region of their forearms under o...

A customized portable SAXS instrument has recently been constructed, installed, and tested at the D22 SANS ILL. Technical characteristics of this newly established plug-and-play system have reported (J. Appl. Cryst. 2020, 53, 722). An optimized lead shielding arrangement on a double energy threshold X-ray detector further implemented to substantially suppress unavoidable high-energy gamma radia...

We report quasi-phase-matched second-harmonic generation in periodically poled lithium niobate (PPLN), where both fundamental and second-harmonic waves are ordinary waves. It provides a lower-limit value for d22 of 1.1 pm/V. The measured temperature and wavelength bandwidth of the second-harmonic signal are in good agreement with the theoretical predictions. Since the d22 = dYYY nonlinear coeff...