نتایج جستجو برای: DHC

تعداد نتایج: 403  

Journal: :Pharmacological reports : PR 2012
Wojciech Leppert Przemysław Mikołajczak Ewa Kamińska Michał Szulc

Aim of the study was to assess dihydrocodeine (DHC) and metabolites concentrations and their correlations with DHC analgesia in cancer patients with pain. Thirty opioid-naive patients with nociceptive pain intensity assessed by VAS (visual analogue scale) > 40 received controlled-release DHC as the first (15 patients, 7 days) or as the second opioid (15 patients, 7 days). Blood samples were tak...

Journal: :Molecules 2017
Huanyu Guan Kaitong Li Xiaoming Wang Xiaomei Luo Meifeng Su Wenting Tan Xiaoyan Chang Yue Shi

Dehydrocorydaline (DHC), a quaternary alkaloid from Corydalis yanhusuo, has been demonstrated to be the active constituent in the treatment of coronary heart disease. In this study, a high-performance liquid chromatography-electrospray ionization-triple quadrupole linear ion trap mass spectrometry (HPLC-ESI-QTRAP MS) technique was used to identify DHC metabolites in plasma and bile after oral a...

Journal: :Molecules 2017
Oreto Fayos Ana Carolina de Aguiar Ana Jiménez-Cantizano Marta Ferreiro-González Ana Garcés-Claver Julián Martínez Cristina Mallor Ana Ruiz-Rodríguez Miguel Palma Carmelo G Barroso Gerardo F Barbero

The ontogenetic variation of total and individual capsaicinoids (nordihydrocapsaicin (n-DHC), capsaicin (C), dihydrocapsaicin (DHC), homocapsaicin (h-C) and homodihydrocapsaicin (h-DHC)) present in Malagueta pepper (Capsicum frutescens) during fruit ripening has been studied. Malagueta peppers were grown in a greenhouse under controlled temperature and humidity conditions. Capsaicinoids were ex...

2016
Zhi-Yu Yin Lu Li Shuai-Shuai Chu Qing Sun Zheng-Liang Ma Xiao-Ping Gu

Dehydrocorydaline (DHC) is an alkaloidal component isolated from Rhizoma corydalis. Previous studies have shown that DHC has anti-inflammatory and anti-tumor effects and that it can protect the cardiovascular system. However, there are few studies of the antinociceptive effects of DHC in vivo. This study explored the antinociceptive effects and possible mechanisms of DHC in mice using two infla...

Journal: :Pharmacological reports : PR 2013
Patrícia Pozzatti Gustavo O Dos Reis Danielle F Pereira Heros Horst Leandro Espindola Melina Heller Gustavo A Micke Moacir G Pizzolatti Tânia S Fröde

BACKGROUND Dihydrocorynantheol (DHC) is an alkaloid compound isolated from Esenbeckia leiocarpa Engl. that has demonstrated anti-inflammatory properties in experimental models. The aim of this study was to investigate whether the modification of the chemical structure of DHC could alter its anti-inflammatory effect in a mouse model of pleurisy induced by carrageenan. METHODS DHC was isolated ...

2015
Young Ho Seo Sung-Su Kim Kwang-Soo Shin

2',4'-Dihydroxychalcone (2',4'-DHC) was identified from a heat shock protein 90 (Hsp90)-targeting library as a compound with Hsp90 inhibitory and antifungal effects. In the presence of 2',4'-DHC (8 µg/mL), radial growth of Aspergillus fumigatus was inhibited 20% compared to the control, and green pigmentation was completely blocked. The expression of the conidiation-associated genes abaA, brlA,...

Journal: :The Journal of pharmacology and experimental therapeutics 2009
Seon-Hee Oh Sung-Chul Lim

Endoplasmic reticulum (ER) stress causes cell survival or death, which is dependent on the type of cell and stimulus. Capsaicin (8-methyl-N-vanillyl-6-nonenamide) and its analog, dihydrocapsaicin (DHC), induced caspase-3-independent/-dependent signaling pathways in WI38 lung epithelial fibroblast cells. Here, we describe the molecular mechanisms induced by both chemicals. Exposure to capsaicin ...

2013
Yan-Wei Hu Xin Ma Jin-Lan Huang Xin-Ru Mao Jun-Yao Yang Jia-Yi Zhao Shu-Fen Li Yu-Rong Qiu Jia Yang Lei Zheng Qian Wang

AIMS Atherosclerosis is a chronic inflammatory disease and represents the major cause of cardiovascular morbidity and mortality. There is evidence that dihydrocapsaicin (DHC) can exert multiple pharmacological and physiological effects. Here, we explored the effect of DHC in atherosclerotic plaque progression in apoE(-/-) mice fed a high-fat/high-cholesterol diet. METHODS AND RESULTS apoE(-/-...

Journal: :Molecular biology of the cell 2000
C A Perrone S H Myster R Bower E T O'Toole M E Porter

To identify domains in the dynein heavy chain (Dhc) required for the assembly of an inner arm dynein, we characterized a new motility mutant (ida2-6) obtained by insertional mutagenesis. ida2-6 axonemes lack the polypeptides associated with the I1 inner arm complex. Recovery of genomic DNA flanking the mutation indicates that the defects are caused by plasmid insertion into the Dhc10 transcript...

2012
Chih-Ya Wang An-Chi Tsai Chieh-Yu Peng Ya-Ling Chang Kuo-Hsiung Lee Che-Ming Teng Shiow-Lin Pan

The traditional Chinese medicine component dehydrocostuslactone (DHC) isolated from Saussurea costus (Falc.) Lipschitz, has been shown to have anti-cancer activity. Angiogenesis is an essential process in the growth and progression of cancer. In this study, we demonstrated, for the first time, the anti-angiogenic mechanism of action of DHC to be via the induction of cell cycle progression at th...

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