نتایج جستجو برای: DNA index

تعداد نتایج: 895728  

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه تبریز - دانشکده علوم پایه 1393

درمان سرطان به صورت قابل توجهی باعث افزایش طول عمر می شود. سیکلوفسفامید یک داروی ضدسرطان است که در شیمی درمانی استفاده می شود، جزء گروه های دارویی آنتی نئوبلاستیک آلکلیله کننده است که با آلکلیله کردن dna، rna آنزیم هایی را که سبب ساختن اسیدهای آمینه در پروتئین ها میشوند را مهار می کند. اثرات جانبی این دارو شامل بی اشتهایی، تهوع، کاهش عملکرد غدد جنسی، ایجاد آمنوره، آزواسپرمی، الیگو اسپرمی، اختلا...

Journal: :Journal of Clinical Pathology 1989

ژورنال: یافته 2020

Background: Various studies proposed virus infection is to be a possible cause of human breast cancer. However, the data argue the association between virus and cancer are inconsistent. This study was conducted to detect whether HPV-DNA is present in tissue samples of breast cancer in Isfahan province. Materials and Methods: Paraffin embedded formalin fixed specimens were prepared from 40 brea...

Journal: :Cancer Cell International 2021

Abstract Background We aimed to develop and validate a predictive model for the overall survival (OS) of patients with nasopharyngeal carcinoma (NPC). Methods Overall, 519 were retrospectively reviewed in this study. In addition, random forest was used identify significant prognostic factors OS among NPC patients. Then, calibration plot concordance index (C-index) utilized evaluate accuracy nom...

Journal: :Journal of surgical oncology 2015
Fritz Klein Marcus Bahra Anja Schirmeier Hussein Al-Abadi Johann Pratschke Uwe Pelzer Helmut Oettle Jana Striefler Hanno Riess Marianne Sinn

BACKGROUND AND OBJECTIVES The continuous progress in treatment options for pancreatic adenocarcinoma has lead to a re-evaluation of prognostic markers. In this study the prognostic relevance of DNA Index and classical histopathological parameters with regard to disease-free (DFS) and overall survival (OS) was analyzed within the CONKO-001 patient population. METHODS One hundred forty three fr...

2012
M. Pradhan V. M. Abeler H. E. Danielsen B. Sandstad C. G. Tropé G. B. Kristensen B. Å. Risberg

BACKGROUND We evaluated the prognostic importance of DNA ploidy in stage I and II endometrioid adenocarcinoma (EAC) of the endometrium with a focus on DNA index. PATIENTS AND METHODS High-resolution DNA ploidy analysis was carried out in tumor material from 937 consecutive patients with International Federation of Gynecology and Obstetrics (FIGO) stage I and II EAC of the endometrium. RESUL...

Journal: :Cancer research 2003
Brant G Wang Han-Yao Huang Yu-Chi Chen Robert E Bristow Keyanunoosh Kassauei Chih-Chien Cheng Richard Roden Lori J Sokoll Daniel W Chan Ie-Ming Shih

Tumor-released DNA in blood represents a promising biomarker for cancer detection. It has been postulated that tumor necrosis causes release of DNA of varying sizes, which contrasts apoptosis in normal tissue that releases smaller and more uniform DNA fragments. To test the hypothesis that increased DNA integrity, i.e., a longer DNA strand, is a tumor-associated marker in plasma, we determined ...

Journal: :Environmental Health Perspectives 1995
J Wakefield-Albers

Out of 130 ovarian cancer patients the DNA index of cells from ovarian carcinoma was studied in 56 cases in which cytospin preparations showed the presence of atypical cells. In 24 patients the population had a diploid DNA index (1.0) and in the others the DNA index ranged from 1.2 to 2.0 (tetraploid). No hypodiploid or hypertetraploid populations were detected. Repeated samples from the same p...

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