نتایج جستجو برای: Dasatinib

تعداد نتایج: 1954  

Dasatinib is a tyrosine kinase inhibitor (TKI) that is used to treat chronic myeloid leukemia and in the management of ulcerative colitis (UC) and to provide appropriate results in treatment. Dasatinib is significantly higher and faster than full cytogenetic and large molecular responses as compared to imatinib. In the recent study, using the NMR data, the frequency and thermochemical propertie...

Dasatinib is a tyrosine kinase inhibitor (TKI) that is used to treat chronic myeloid leukemiaand in the management of ulcerative colitis (UC) and to provide appropriate results in treatment. Dasatinib is significantly higher and faster than full cytogenetic and large molecular responses as compared to imatinib. In the recent study, using the NMR data, thermochemical properties of the dasa...

Journal: :Haematologica 2013
Devendra K Hiwase Verity A Saunders Eva Nievergall Douglas D Ross Deborah L White Timothy P Hughes

Dasatinib is effective in most chronic phase chronic myeloid leukemia patients both in first-line therapy and following imatinib failure. While imatinib uptake into CD34(+) cells is low compared to mononuclear cells, few data evaluate how well dasatinib targets primitive CML cells. This study compares intracellular concentration of dasatinib and Bcr-Abl kinase inhibition in CML-CD34(+) progenit...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2007
Oliver Hantschel Uwe Rix Uwe Schmidt Tilmann Bürckstümmer Michael Kneidinger Gregor Schütze Jacques Colinge Keiryn L Bennett Wilfried Ellmeier Peter Valent Giulio Superti-Furga

Dasatinib is a small-molecule kinase inhibitor used for the treatment of imatinib-resistant chronic myelogenous leukemia (CML). We have analyzed the kinases targeted by dasatinib by using an unbiased chemical proteomics approach to detect binding proteins directly from lysates of CML cells. Besides Abl and Src kinases, we have identified the Tec kinases Btk and Tec, but not Itk, as major binder...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2011
Juan Carlos Montero Samuel Seoane Alberto Ocaña Atanasio Pandiella

Dasatinib is a small molecule tyrosine kinase inhibitor that targets a wide variety of tyrosine kinases implicated in the pathophysiology of several neoplasias. Among the most sensitive dasatinib targets are ABL, the SRC family kinases (SRC, LCK, HCK, FYN, YES, FGR, BLK, LYN, and FRK), and the receptor tyrosine kinases c-KIT, platelet-derived growth factor receptor (PDGFR) α and β, discoidin do...

Journal: :Blood 2012
Krisztina Futosi Tamás Németh Robert Pick Tibor Vántus Barbara Walzog Attila Mócsai

Dasatinib is a tyrosine kinase inhibitor used to treat imatinib-resistant chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia. At present, little is known about how dasatinib influences nonmalignant cells. In the present study, we tested the effect of dasatinib on functional responses of normal mature human neutrophils. Dasatinib completely blocked integri...

Journal: :Investigative ophthalmology & visual science 2013
Kazuhiko Umazume Lanhsin Liu Patrick A Scott Juan P Fernandez de Castro Kevin McDonald Henry J Kaplan Shigeo Tamiya

PURPOSE We tested the efficacy of dasatinib, a Food and Drug Administration (FDA)-approved tyrosine kinase inhibitor, to prevent proliferative vitreoretinopathy (PVR). METHODS The effect of dasatinib on RPE sheet growth was determined by measuring enlargement of cultured RPE sheets in the presence or absence of dasatinib. Epithelial-mesenchymal transition (EMT) of RPE cells was assessed by ex...

2011
Juan Carlos Montero Samuel Seoane Alberto Ocaña Atanasio Pandiella

Dasatinib is a small molecule tyrosine kinase inhibitor that targets a wide variety of tyrosine kinases implicated in the pathophysiology of several neoplasias. Among the most sensitive dasatinib targets are ABL, the SRC family kinases (SRC, LCK, HCK, FYN, YES, FGR, BLK, LYN, and FRK), and the receptor tyrosine kinases c-KIT, platelet-derived growth factor receptor (PDGFR) a and b, discoidin do...

2011
Juan Carlos Montero Samuel Seoane Alberto Ocaña Atanasio Pandiella

Dasatinib is a small molecule tyrosine kinase inhibitor that targets a wide variety of tyrosine kinases implicated in the pathophysiology of several neoplasias. Among the most sensitive dasatinib targets are ABL, the SRC family kinases (SRC, LCK, HCK, FYN, YES, FGR, BLK, LYN, and FRK), and the receptor tyrosine kinases c-KIT, platelet-derived growth factor receptor (PDGFR) a and b, discoidin do...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2008
Devendra K Hiwase Verity Saunders Duncan Hewett Amity Frede Stephanie Zrim Phuong Dang Laura Eadie L Bik To Junia Melo Sharad Kumar Timothy P Hughes Deborah L White

PURPOSE The organic cation transporter OCT-1 mediates active transport of imatinib. We recently showed that low OCT-1 activity is a major contributor to suboptimal response in chronic myeloid leukemia (CML) patients treated with imatinib. The relevance of OCT-1 activity and efflux pumps in determining intracellular uptake and retention (IUR) of dasatinib was assessed. EXPERIMENTAL DESIGN The ...

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