contact hypersensitivity (chs) mouse model induced by 2, 4-dinitrofluorobenzene (dnfb) is thought to be a t helper 1 (th1)-dominant response and used for investigating anti-inflammatory and immunosuppressive agents. however, it is hardly used for screening large-scale drugs because of the large number of animals and complex mechanisms involved in-vivo. in this study, we focused on whether t lym...

in this study, we investigate the immunostimulatory effects of alcoholic extract of the coffee seed on cell-mediated immune response andcyclophosphamide-induced (cp) immunosuppressed mice. the assessment of cellular immune function was carried out by the measurement of delayed-type hypersensitivity (dth) response. according to the literature survey, cyclophosphamide has only suppressing effect ...

studies have demonstrated that plant extracts possess various biological characteristics, including immunomodulatory activity. heracleum persicum desf. (apiaceae), a medicinal plant native to iran, was studied for its immunomodulatory activity. immunomodulatory activity of different doses of an aqueous extract of h. persicum, was evaluated in female swiss albino mice. mice were treated with thr...

background: various compounds of plant origin have been widely investigated since ancient times for their possible immunomodulatory properties as well as for the treatment of a wide range of diseases. objective: to study the immunomodulatory functions of the aqueous extract of the seeds of abrus precatorius commonly known as indian liquorice (fabaceae), a medicinal plant native to central india...

in agriculture, an application that accounts for approximately 40% of the total production of these agents. It is obviously impossible to give detailed descriptions of the many excellent papers in this volume, but some points may be noted. From a pharmacological viewpoint, the area of structure-activity relationships is particularly well covered in regard to penicillins (K. et al.) and lincomyc...

Exposure to picryl guinea pig albumin with 3-6 picryl groups per mole failed to affect the ability of peritoneal exudate or peripheral blood leukocytes from sensitized donors to transfer delayed sensitivity to normal recipients. In contrast, conjugates containing 40-48 picryl groups per mole altered the ability of exposed leukocytes to transfer delayed sensitivity. Evidence is presented that hi...

Guinea pigs infected by intradermal injection of living toxigenic diphtheria bacilli and protected by horse antitoxic globulin, given either before or after infection, develop delayed hypersensitivity of the tuberculin type to diphtherial proteins. The highest degree of hypersensitivity is specifically directed against diphtheria toxin (or toxoid) itself, although smaller delayed skin reactions...

flavonoids are potentially immunomodulatory factors and it may be inferred that these phytochemicals contribute to immunomodulatory properties of the allium family. in the present study, we investigated the potential mechanism underlying the immunomodulatory effect of shallot and its ethyl acetate (ea) fraction as flavonoid-rich sources. ex vivo, effects of a hydroalcoholic extract of shallot, ...