نتایج جستجو برای: Deleted azoospermia‚ Azoospermia factor‚ STS marker

تعداد نتایج: 973199  

M Motvali bashi R Mahmodi Z Hojati Z Rezaei

Background & Aims: The most significant cause of infertility in men is the genetic deletion in the azoospermia factor (AZF) region that is caused by the process of intra- and inter-chromosomal homologous recombination in amplicons. Homologous recombination could also result in partial deletions in AZF region. The aim of this research was to determine the association between the partial AZFc del...

Journal: :iranian journal of public health 0
m aarabi dept. of reproductive genetics and biotechnology, reproductive biotechnology research center, avesin k saliminejad dept. of reproductive genetics and biotechnology, reproductive biotechnology research center, avesin mr sadeghi dept. of reproductive genetics and biotechnology, reproductive biotechnology research center, avesin h soltanghoraee avesina infertility clinic, avesina research institute, tehran, iran n amirjannati avesina infertility clinic, avesina research institute, tehran, iran mh modarressi

background: deletions of the daz (deleted in azoospermia) genes within the human y chromosome's azfc region are the most common cause of spermatogenesis failure. these deletions are usually assessed by analyses of genomic dna ex­tracted from peripheral leukocytes. daz genes are expressed in male germ cells. in this prospective study, we investigated daz expression and deletion in 102 consecutiv...

Journal: :medical journal of islamic republic of iran 0
h najmabadi from the welfare science and rehabilitation university (hn), tehran, iran; karimi-nejad pathology & genetic center (hn, ss, fs), tehran, iran; division of endocrinology, metabolism, and molecularmedicine (kk. wt, lr, an, mg, sb) and department of obstetrics and gynecology (bs), charles r.drew university of medicine and science, los angeles, ca, usa; department of obstetrics andgynecology, university of melbourne, australia; institute of reproduction and development (dmdk,rim. kal), monash university, melbourne, australia, and prince henry:s medical research institute (rimc), and karolinska institute, stokholm, sweden (s a). dm de kretser s arver w taylor c mallidis hw gorden baker

it is now agreed that 10-25% of infertile men with azoospermia have submicroscopic deletions of the y chromosome long ann (yq), consistent with the proposed location of the azoospermia locus (azf) in yq 11.23. however, it is not known whether yq microdeletions are unique to men with azoospermia or whether they are also observed in infertile men with less severe defects of spermatogenesis (oligo...

Journal: :Genetics and molecular research : GMR 2015
C L Wei J L Cheng W C Yang L Y Li H C Cheng J J Fu

Y chromosomal microdeletions at the azoospermia factor locus and chromosome abnormalities have been implicated as the major causes of idiopathic male infertility. A marker chromosome is a structurally abnormal chromosome in which no part can be identified by cytogenetics. In this study, to identify the origin of the marker chromosomes and to perform a genetic diagnosis of patients with azoosper...

Journal: :international journal of reproductive biomedicine 0
neda heydarian raha favaedi mohammad ali sadighi gilani maryam shahhoseini

background: the availability of testis specific genes will be of help in choosing the most promising biomarkers for the detection of testicular sperm retrieval in patients with non-obstructive azoospermia (noa). testis specific chromodomain protein y 1 (cdy1) is a histone acetyltransferase which concentrates in the round spermatid nucleus, where histone hyperacetylation occurs and causes the re...

A NIEVA, B SUH, C MALLIDIS, DM De KRETSER, F SAHEBJAM, H NAJMABADI, HW GORDEN BAKER, KA LOVELAND, L RAMIREZ, M GUTIERREZ, RI McLACHLAN, S ARVER, S BHASIN, S SAHEBJAM, W TAYLOR,

It is now agreed that 10-25% of infertile men with azoospermia have submicroscopic deletions of the Y chromosome long ann (yq), consistent with the proposed location of the azoospermia locus (AZF) in Yq 11.23. However, it is not known whether Yq microdeletions are unique to men with azoospermia or whether they are also observed in infertile men with less severe defects of spermatogenesis (o...

Background and Aim: The Y-chromosome azoospermic factor (AZF) regions consist of genes whose specific roles and functions in spermatogenesis and fertility have not been completely clarified. Hence, recognition of the association between AZF microdeletions and male infertility has suggestions for the diagnosis, treatment, and genetic counseling. The main objective of the present study was invest...

Journal: :Human reproduction 2002
G R Dohle D J J Halley J O Van Hemel A M W van den Ouwel M H E C Pieters R F A Weber L C P Govaerts

BACKGROUND Male infertility due to severe oligozoospermia and azoospermia has been associated with a number of genetic risk factors. METHODS In this study 150 men from couples requesting ICSI were investigated for genetic abnormalities, such as constitutive chromosome abnormalities, microdeletions of the Y chromosome (AZF region) and mutations in the cystic fibrosis transmembrane conductance ...

2017
Ki Eun Kim Ye Jin Kim Mo Kyoung Jung Hyun-Wook Chae Ah Reum Kwon Woo Jung Lee Duk-Hee Kim Ho-Seong Kim

A 15-year-old boy was referred due to gynecomastia and short stature. He was overweight and showed the knuckle-dimple sign on the left hand, a short fourth toe on the left foot, and male external genitalia with a small phallus. His levels of estradiol and follicle-stimulating hormone were increased, and his testosterone concentration was normal. Other hormonal tests were within the normal range...

Journal: :Urology journal 2006
Mir Davood Omrani Saied Samadzadae Mortaza Bagheri Kiarash Attar

INTRODUCTION Although assisted reproduction techniques are used extensively in Iran, screening for Y chromosome microdeletions before intracytoplasmic sperm injection is often undervalued. Our aim was to investigate Y chromosome microdeletions in men with idiopathic azoospermia or severe oligospermia. MATERIALS AND METHODS In 99 selected patients with azoospermia or severe oligospermia and el...

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