نتایج جستجو برای: Dendrimers

تعداد نتایج: 3050  

Journal: :modares journal of medical sciences: pathobiology 2015
farnoush jafari iri sofla fatemeh rahbarizadeh davoud ahmadvand

objective: generation 5 poly (amidoamine) dendrimers are promising multipotent gene delivery vectors that provide favorable dna condensation properties; however, their high toxicity limits their applications. toxicity of pamam dendrimers depends on their type, generation and applied dosage in a way that lower generations (lower than g5 dendrimers) and anionic dendrimers have lower toxicity than...

2015
Yubin Li Haiyan Zhu Shaofei Wang Xiaolu Qian Jiajun Fan Ziyu Wang Ping Song Xuesai Zhang Weiyue Lu Dianwen Ju

Poly-amidoamine (PAMAM) dendrimers are proposed to be one of the most promising drug-delivery nanomaterials. However, the toxicity of PAMAM dendrimers on the central nervous system seriously hinders their medical applications. The relationship between oxidative stress and autophagy induced by PAMAM dendrimers, and its underlying mechanism remain confusing. In this study, we reported that PAMAM ...

Journal: :Molecules 2018
Anne-Marie Caminade Jean-Pierre Majoral

Among the six Critical Nanoscale Design Parameters (CNDPs) proposed by Prof. Donald A. Tomalia, this review illustrates the influence of the sixth one, which concerns the elemental composition, on the properties of dendrimers. After a large introduction that summarizes different types of dendrimers that have been compared with PolyAMidoAMine (PAMAM) dendrimers, this review will focus on the pro...

Journal: :Molecules 2016
Alan E Enciso Barry Neun Jamie Rodriguez Amalendu P Ranjan Marina A Dobrovolskaia Eric E Simanek

Triazine and PAMAM dendrimers of similar size and number of cationic surface groups were compared for their ability to promote platelet aggregation. Triazine dendrimers (G3, G5 and G7) varied in molecular weight from 8 kDa-130 kDa and in surface groups 16-256. PAMAM dendrimers selected for comparison included G3 (7 kDa, 32 surface groups) and G6 (58 kDa, 256 surface groups). The treatment of hu...

Journal: :Journal of Drug Delivery and Therapeutics 2022

Dendrimers are symmetric molecules; their size is within the nanoscale. Its structure usually homogeneous and monodisperse; they composed of a nucleus several layers 1. The number that dendrimer has defines its generation. There different types dendrimers. synthesis these macromolecules carried out following steps growth activation, organic reactions required to obtain branched structure2. Alth...

2010
Sushma Drabu Smriti Khatri Sheveta Babu

Dendrimers are new class of polymeric materials. It is generally described as a macromolecule, which is characterized by its extensively branched 3D structure that provides a high degree of surface functionality and versatility. Dendrimers are highly branched, globular macromolecules with many arms emanating from a central core. The unique properties associated with these dendrimers such as uni...

Journal: :Acta biomaterialia 2012
Fei Wang Xiaopan Cai Yunzhang Su Jingjing Hu Q Wu Hongfeng Zhang Jianru Xiao Yiyun Cheng

Polypropylenimine (PPI) dendrimers have been widely used as effective delivery vehicles for drugs and nucleic acids during the past decade. However, biomedical applications of PPI dendrimers were limited because of their serious cytotoxicity and low drug loading capacity. In the present study, acetylated PPI dendrimers with different degrees of acetylation ranging from 14.2% to 94.3% were synth...

Journal: :Journal of Chemistry 2021

Dendrimers are highly branched, star-shaped macromolecules with nanometer-scale dimensions. defined by three components: a central core, an interior dendritic structure (the branches), and exterior surface functional groups. Topological indices numerical numbers that help us to understand the topology of different dendrimers can be used predict properties without performing experiments in wet l...

Journal: :Cellular & molecular biology letters 2002
Barbara Klajnert Maria Bryszewska

Dendrimers are a relatively new class of polymer, with well-defined molecular structures. They are synthesized from a polyfunctional core by adding branched monomers that react with the functional groups of the core, in turn leaving end groups that can react again. This results in a large number of reactive terminal groups that increases after each cycle or " generation ". The structure of a gi...

Journal: :Molecules 2013
Ruth Hemmer Andrew Hall Robert Spaulding Brett Rossow Michael Hester Megan Caroway Anthony Haskamp Steven Wall Heather A Bullen Celeste Morris Kristi L Haik

Dendrimers are highly customizable nanopolymers with qualities that make them ideal for drug delivery. The high binding affinity of biotin/avidin provides a useful approach to fluorescently label synthesized dendrimer-conjugates in cells and tissues. In addition, biotin may facilitate delivery of dendrimers through the blood-brain barrier (BBB) via carrier-mediated endocytosis. The purpose of t...

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