objective(s) in recent years concerns have been raised regarding the incidence of male reproductive disorders from exposure to endocrine disruptors. so, chronic effects of di(2-ethylhexyl)phthalate were studied on histological and stereological structure of testis in adult wistar rats. materials and methods thirty two adult wistar rats were randomly divided in four equal experiment groups; oil ...

Introduction: Di (2-ethylhexyl) phthalate is one of the most abundant phthalate esters and it is widely used as softeners in plastic products. Malformation, carcinogenicity, the poisoning of the reproductive system, and also the disruption of the human endocrine system are the harmful effects of these substances. Materials and Methods: In this research, the removal of di (2-ethylhexyl) phthal...

The effects of mono- and dibutyl phthalate and mono- and di(2-ethylhexyl) phthalate on energy-dependent K+ uptake, respiration rates, and succinate cytochrome c reductase activities of isolated rat liver mitochondria were evaluated. The energy-coupling processes, active K+ transport and oxidative phosphorylation, were affected most by di-n-butyl phthalate and mono(2-ethylhexyl) phthalate. Mono-...

Since that time, new data have become available, and these have been incorporated into the monograph and taken into consideration in the present evaluation. Chem. Abstr. Name: 1,2-Benzenedicarboxylic acid, bis(2-ethylhexyl) ester IUPAC Systematic Names: Bis(2-ethylhexyl) phthalate; phthalic acid, bis(2-ethyl-hexyl) ester Synonyms: Bis(2-ethylhexyl) 1,2-benzenedicarboxylate; bis(2-ethylhexyl) or...

background: phthalate esters have been shown to cause reproductive toxicity in both developing and adult animals. objective: this study was designed to assess long-term effects of maternal exposure to di (2-ethylhexyl) phthalate (dehp) on reproductive ability of both neonatal and adult male offspring. materials and methods: 60 female rats randomly divided in four equal groups; vehicle control a...

Two cathepsin B inhibitors were isolated from the culture supernatant of a marine Pseudomonas sp. PB01 (GenBank Accession No. EU126129). Their structures were elucidated by spectroscopic analyses as dibutyl phthalate and di-(2-ethylhexyl) phthalate. Both dibutyl phthalate and di-(2-ethylhexyl) phthalate showed dose-dependent cathepsin B inhibitions with IC(50) of 0.42 and 0.38 mM, respectively....

The phthalate ester di-(2-ethylhexyl) phthalate is extensively used as a plasticizer in polyvinyl chloride formulations, where it may constitute up to 40% of the weight of the finished product (Autian, 1973). Di-(2-ethylhexyl) phthalate is widely distributed in the environment, having been detected in various forms of marine life (Mayer et al., 1972), soil samples (Ogner & Schnitzer, 1970) and ...

Five phthalate ester and related compounds (phthalic anhydride, phthalamide, di(2-ethylhexyl) phthalate, di(2-ethylhexyl) adipate and butyl benzyl phthalate) have been tested for carcinogenic effects in standard lifetime rodent feeding studies. Groups of 50 male and female rats and mice were fed diets containing various concentrations of the test chemicals for 102-106 consecutive weeks. The die...

The mutagenic activities of several phthalate esters have been evaluated in an 8-azaguanine resistance assay in Salmonella typhimurium. Three phthalate esters were found to be mutagenic: dimethyl phthalate, diethyl phthalate and di-n-butyl phthalate. A number of other phthalate esters were not found to be mutagenic, including di(2-ethylhexyl) phthalate, di-n-octyl phthalate, diallyl phthalate, ...

AIMS As growing concerns exist regarding phthalate exposure, which could be teratogenic, carcinogenic or induce reproductive toxicity, we aimed to review the evidence of the risks due to the use of medical devices containing di(2-ethylhexyl)phthalate in hospitalized neonates. METHODS We reviewed the literature, searching through medical literature databases (Pubmed, MEDLINE, EBM reviews, Coch...