As digital microfluidic biochips become widespread in safety-critical biochemical applications, system dependability emerges as a critical performance parameter. The dynamic reconfigurability inherent in digital microfluidic biochips can be utilized to bypass faulty cells, thereby supporting defect/fault tolerance. In this paper, we propose three different reconfiguration techniques and the cor...

A Digital Microfluidic Biochip (DMFB) offers a promising platform for medical diagnostics, DNA sequencing, Polymerase Chain Reaction (PCR), and drug discovery and development. Conventional Drug discovery procedures require timely and costly manned experiments with a high degree of human errors with no guarantee of success. On the other hand, DMFB can be a great solution for miniaturization, int...

Microfluidic-based biochips are soon revolutionizing clinical diagnostics and many biochemical laboratory procedures due to their advantages of automation, cost reduction, portability, and efficiency [18]. Conventional technology depends on the manipulation of continuous liquid flow through microfabricated channels. However, actuation of flow is implemented with external assistance of micro-pum...

Dependability is an essential attribute for microfluidic biochips that are being developed for safety-critical applications such as point-of-care health assessment, air-quality monitoring, and food-safety testing. Therefore, these devices must be adequately tested after manufacture and during bioassay operations. This paper describes testing and diagnosis techniques for droplet-based "digital" ...

Microfluidics-based biochips are soon expected to revolutionize clinical diagnosis, DNA sequencing, and other laboratory procedures involving molecular biology. As more bioassays are executed concurrently on a biochip, system integration and design complexity are expected to increase dramatically. Current techniques for full-custom design of digital microfluidic biochips however do not scale we...

This paper deals with the development of a microfluidic biochip for the exposure of living cells to nanosecond pulsed electric fields (nsPEF). When exposed to ultra short electric pulses (typical duration of 3-10ns), disturbances on the plasma membrane and on the intra cellular components occur, modifying the behavioral response of cells exposed to drugs or transgene vectors. This phenomenon pe...

1. Abstract In the previous checkpoint, design for biochips (see Figure 1). Figure 1: We are addressing the highlighted components have developed a placement algorithm for inserting microfluidic modules onto the biochip. After that, we inject runtime defects to simulate on biochip. Finally, we perform module reconfiguration to unused defect-free cells. 2.1 Microfluidic Module Library Performing...