Background: Heart failure is one of the common cardiovascular diseases and digoxin has the positive effect on it. But unfortunately in spite of its positive effect on heart failure therapeutic and toxic level of it in patients is different and close to each other. The aim of this research was determination of digoxin serum level in failur heart patients. Materials and methods: In this cros...

decreased cardiac responsiveness to adrenergic stimulation has been observed in cholestatic liver disease, but the cause remains unclear. previous reports have suggested that nitric oxide overproduction might have a role in cholestasis-induced bradycardia via inhibition of l-type calcium channels. in the present study, the digoxin has been used to increase cardiac ca2+ transient in male sprague...

introduction: cardiac glycosides such as digoxin or digitoxin are the natural products that are traditionally used to increase cardiac contractile force in patients with heart failure and cardiac arrhythmias. it has been shown that digoxin can directly inhibit the cell proliferation and lead to cell apoptosis. present study was conducted to analyze the effect of digoxin in the cohorts of mesenc...

in this study we produced and purified a high titer of specific and high affin¬ity fab fragments of anti-digoxin antibody. immunization of rabbits with a conju¬gate of the cardiac glycoside digoxin, coupled by a periodate oxidation method to the amino group of lysine in bovine serum albumin resulted in the production of this type of high titer digoxin-specific antibodies with exceptionally high...

Objectives: Digoxin is an antiarrhythmic drug with a narrow therapeutic range and used in clinical conditions such as heart failure atrial fibrillation. The planar frontal QRS-T angle reflects the deviations between depolarization repolarization of ventricles, it has been reported that increase this associated mortality. In our study, relationship digoxin use blood level was investigated. Metho...

This case report describes several electrocardiographic findings in an 8-years old female Pomeranian dog that was referred with a history of digoxin overdose. Electrocardiographic abnormalities detected in this case could be classified as primary electrocardiographic disturbances, reflecting cardiac chamber enlargement and secondary ECG changes, attributed to digoxin toxicity. ECG manifestatio...

Decreased cardiac responsiveness to adrenergic stimulation has been observed in cholestatic liver disease, but the cause remains unclear. Previous reports have suggested that nitric oxide overproduction might have a role in cholestasis-induced bradycardia via inhibition of L-type calcium channels. In the present study, the digoxin has been used to increase cardiac Ca2+ transient in male Sprague...

Toxicity from digitalis is a typical clinical issue. In this case, the interaction of digoxin and furosemide becoming more widely recognised as major cause toxicity. We present an abnormal ECG that demonstrates digoxin-induced cardiotoxicity. report case Digoxin toxicity in 79-year-old male patient admitted with complains nausea, increase frequency micturition, decrease appetite, nocturia, shor...

The purpose of this investigation was to evaluate the effect of digoxin on aerobic performance in mildly symptomatic patients with congestive heart failure and sinus rhythm. Ten patients (8 men and 2 women) with idiopathic dilated cardiomyopathy (ejection fraction 17 to 33%, mean 27 +/- 4%) who were stable and mildly symptomatic with maintenance digoxin and diuretic therapy were studied. All pa...

To investigate the basis for a clinically important digitalis-quinidine interaction that is characterized by increases in serums digoxin concentrations when quinidine is administered to digoxin-treated patients, we have studied in vitro the interaction of quinidine with the digoxin receptor. Evidence has been obtained that quinidine is capable of decreasing the affinity for digoxin of cardiac g...