in this study, the effects of various hydrophilic (hpmc and carbopol 971) and plastic (ethylcellulose and eudragit rl100) polymers on the release profile of diltiazem hcl from matrix tablets were evaluated in-vitro. for this purpose, tablets containing 60 mg of diltiazem hcl along with various amounts of the aforementioned polymers were prepared using the wet granulation technique. tablets prep...

In this study, the effects of various hydrophilic (HPMC and Carbopol 971) and plastic (Ethylcellulose and Eudragit RL100) polymers on the release profile of diltiazem HCl from matrix tablets were evaluated in-vitro. For this purpose, tablets containing 60 mg of diltiazem HCl along with various amounts of the aforementioned polymers were prepared using the wet granulation technique. Tablets prep...

The present work showed that the iontophoretic approach was feasible to enhance transdermal drug delivery of drug. In vitro horizontal cell has been developed to co-relate with in vivo iontophoretic drug delivery more closely. Two electrodes were positioned on the either side of the epithelial. Iontophoretic delivery of Diltiazem HCl across porcine ear skin increased proportional to (a) Increas...

Hypertens ion: Diltiazem HCl CD produces its antihypertensive effect primarily by relaxation of vascular smooth muscle and the resultant decrease in peripheral vascular resistance. The magnitude of blood pressure reduction is related to the degree of hypertension; thus hypertensive individuals experience an antihypertensive effect, whereas there is only a modest fall in blood pressure in normot...

In this study, the effects of various hydrophilic (HPMC and Carbopol 971) and plastic (Ethylcellulose and Eudragit RL100) polymers on the release profile of diltiazem HCl from matrix tablets were evaluated in-vitro. For this purpose, tablets containing 60 mg of diltiazem HCl along with various amounts of the aforementioned polymers were prepared using the wet granulation technique. Tablets prep...

The main objective of the present study was to develop matrix-moderated transdermal systems of Diltiazem HCl using various proportions of Ficus reticuleta fruit mucilage. Physical evaluation was performed such as moisture content, moisture uptake, tensile strength, flatness and folding endurance. In-vitro penetration studies were performed in a Keshary-Chien diffusion cell. The matrix-type tran...

Chitosan/ghatti gum polyelectrolyte complexes were synthesized using different proportions of chitosan (CH) and ghatti gum (GG). The optimum CH: GG ratio was 20:80, which produced highest product yield. Polyelectrolyte (PEC) samples were characterized by differential scanning calorimetry (DSC) and FT-IR spectroscopy. Matrix tablets using PEC as matrix and Diltiazem Hcl as a model drug were form...

this paper reviews the use of texture analysis in studying the performance of hydrophilic matrices of highly soluble drugs and different types of excipients (i.e. water-soluble, water-insoluble and swellable, and water insoluble and non-swellable). tablets were prepared by direct compression, and their swelling and erosion in presence of these different excipients were assessed with the help of...