Aim: Dimedone , gamma pyrone and barbituric acid and their derivatives have also been found to be very important from their application point of view. Thus our aim was to prepare more derivatives from them. Method : Dimedone , gamma pyrone and barbituric acid have been treated with dimethyl sulphoxide and acetic anhydride reagent under varying temperature conditions in order to get more compoun...

Protein sulfenic acids are reactive, reversibly oxidized cysteinyl residues with roles in redox catalysis and regulation. Detection and quantification of these species in proteins is accomplished through chemical modification by reagents such as 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole (NBD chloride), 2-nitro-5-thiobenzoate (TNB), dimedone, or derivatives of dimedone, followed by UV-visible spec...

The reversible oxidation of protein cysteine residues (Cys-SH) is a key reaction in cellular redox signaling involving initial formation of sulfenic acids (Cys-SOH), which are commonly detected using selective dimedone-based probes. Here, we report that significant portions of dimedone-tagged proteins are susceptible to cleavage by DTT reflecting the presence of perthiosulfenic acid species (Cy...

An efficient one pot coupling of aldehydes, dimedone, ammonium acetate and ethyl acetoacetate by using catalytic amount of enneamolybdomanganate(IV) is reported. Various polyhydroquinoline derivatives have been prepared in high yields and comparatively less reaction time.

Cysteine sulfenic acids in proteins can be identified by their ability to form adducts with dimedone, but this reagent imparts no spectral or affinity tag for subsequent analyses of such tagged proteins. Given its similar reactivity toward cysteine sulfenic acids, 1, 3-cyclohexadione was synthetically modified to an alcohol derivative and linked to fluorophores based on isatoic acid and 7-metho...

Symmetrical and non-symmetrical diimines derived from dimedone were synthesized by the reaction of their corresponding enaminothiones with primary amines. The synthesized compounds were characterized using micro analytical data and NMR spectroscopy. Theoretical calculations by B3LYP/6-31G(d,p) level of theory show that the enolic form is the most stable within the possible tautomeric forms of t...

A facile and convenient protocol was developed for the fast (2.5-3.5 h) and high yielding (70-90%) synthesis of fused 1,4-dihydropyridines from dimedone in the presence of HY-zeolite as an efficient recyclable heterogeneous catalyst.

The selective hydrogenation of dimedone (1) to the corresponding monoketone 2 over palladium and Amberlyst 15 ® is reported. The product is a synthetic building block for the fragrance and pharmaceutical industry. Advantages of the new catalytic procedure are the high catalyst activity and selectivity, less by-product formation, avoidance of the presence of acid, and consequently, less salt for...