Bonventre, J. V., M. Brezis, N. Siegel, S. Rosen, D. Portilla, and M. Venkatachalam. Acute renal failure. I. Relative importance of proximal vs. distal tubular injury. In: Acute renal failure forum, edited by W. Lieberthal and S. K. Nigam. Am. J. Physiol. 275 (Renal Physiol. 44): F623–F632, 1998.—For more than 15 years, there has been an ongoing debate regarding the nephron segment(s) most seve...

15’ Practical session Fraser Symmans, Jorge ReisFilho (discussants) 20’ How to assess HER2 status revisited Giuseppe Viale 15’ Practical session Giuseppe Viale, Jorge Reis-Filho (discussants) 20’ How to count and what to count for Ki67 Carsten Denkert 15’ Practical session Carsten Denkert, Jorge ReisFilho (discussants) 15’ Who takes advantage from central pathology review in clinical trials? Gi...

Antibody-drug conjugates (ADCs) combine cytotoxic chemotherapy and antibody specificity. There are 4 components of ADC technology: the cancer, or target, antigen; the antibody to that target; the linker that connects the drug to the antibody; and the drug itself. The antibody directs the cytotoxic agent to the tumor cell, thereby diminishing the side effect profile of the cytotoxic agent and en...

First of all, we would like to thank all the discussants for their interesting, thought–provoking comments and thorough investigation. We also thank the editors for the opportunity to comment briefly on a few issues raised in the discussions. The comments of the discussants underline importance of the topic discussed in our paper, namely, that of application of convex optimization methodology t...

We would like to thank the discussants for the valuable insights and for commenting on important aspects of model checking that we did not touch in our paper. Our goal was modest (but crucial): to select an appropriate distribution with which to judge the compatibility of the data with a hypothesized (hierarchical) model, when the test statistic is not ancillary and an improper prior is used fo...

Background: Malnutrition resulting from inappropriate and ineffective childhood feeding remains a significant public health concern especially in developing countries, where poor child feeding practices exert serious negative impact on health outcomes. This qualitative study explored mothers’ perception about complementary feeding, mothers’ hygiene and food safety measures, food storage, and pr...

We would like to thank the editors and referees for their considerable efforts that improved our paper, and all of the discussants for their feedback, and their thoughtful and stimulating comments. Linear models are central in applied statistics, and inference for adaptive linear modeling is an important active area of research. Our paper is clearly not the last word on the subject! Several of ...