clarithromycin (cla), a broad-spectrum macrolide, is a poorly soluble drug with dissolution rate limited absorption. the aim of this investigation was to prepare cla nanoparticles from a ternary ground mixture in the presence of sodium lauryl sulfate (sls) and polyvinyl pyrrolidone (pvp) as co-grinding water-soluble compounds, in order to improve the drug dissolution rate. different weight rati...

diosmin, a vascular-protecting agent, is practically insoluble in water, and its oral absorption is limited by its extremely low dissolution rate. in this study, β-cyclodextrin (βcd) and 2-hydroxypropyl-β-cyclodextrin (hpβcd) were obtained to improve the solubility and dissolution rate of diosmin. phase solubility studies of diosmin with βcd and hpβcd in distilled water were conducted to charac...

viral hepatitis, as an international public health concern, seriously affects communities and health system. in recent years, great strides have been taken for development of new potential tools against viral hepatitis. among these efforts, a valuable strategy introduced new molecules called “aptamers”. aptamers as potential alternatives for antibodies could be directed against any protein in i...

the present study deals with characterization of dispersions of a poorly water-soluble drug, celecoxib (clx) in polyvinyl caprolactame–polyvinyl acetate–polyethylene glycol graft copolymer (soluplus® (sol)) prepared by different techniques. dispersions of clx in sol at different ratios (2:1, 1:1, 1:2, 1:4 and 1:6) were prepared by spray drying, conventional solvent evaporation and melting metho...

the potential of liquisolid systems to improve the dissolution properties of a water-insoluble agent (indomethacin) was the purpose of this survey. in this study, different formulations of liquisolid tablets using different co-solvents (non-volatile solvents) were prepared and the effect of several amounts of them on the dissolution behaviour of indomethacin was investigated. it is worth mentio...

dissolution pressure and nozzle temperature effects on particle size and distribution were investigated for ress (rapid expansion of supercritical solution) process. supercritical co2 was used as solvent and ibuprofen was applied as the model component in all runs. the resulting ibuprofen nano-particles (about 50 nm in optimized runs) were analyzed by sem and laser diffraction particle size ana...

solid dispersions in water-soluble carriers have attracted considerable interest as a means of improving the dissolution rate, and hence possibly bioavailability, of a range of hydrophobic drugs. the poor solubility of carvedilol leads to poor dissolution and hence variation in bioavailability. the purpose of the present investigation was to increase the solubility and dissolution rate of carve...

Solubility of drug plays a prime role in controlling its dissolution from dosage form. Aqueous solubility of drug is a major factor that determines its dissolution rate. Minimum aqueous solubility of 1% is required to avoid potential solubility limited absorption problems. Studies of 45 compound of different chemical classes and a wide range of solubilities revealed that initial dissolution rat...

Clarithromycin (CLA), a broad-spectrum macrolide, is a poorly soluble drug with dissolution rate limited absorption. The aim of this investigation was to prepare CLA nanoparticles from a ternary ground mixture in the presence of sodium lauryl sulfate (SLS) and polyvinyl pyrrolidone (PVP) as co-grinding water-soluble compounds, in order to improve the drug dissolution rate. Different weight rati...